Thin-layer and gas chromatography, spectrophotometry and mass-spectrometry were employed in studying metabolism of the neuroleptic azabutyron in man. It was ascertained that azabutyron is eliminated from the human organism in 24 hours unchanged (10 per cent of the dose administered). The main ways of its metabolism are oxidative N-dealkylation, reduction of the carboxylic group in the molecule, N-oxidation and conjugation of the drug.
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