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Transfusion-associated graft-versus-host disease in an immunocompetent individual.
BMJ Case Rep
October 2024
Internal Medicine, The Aga Khan University, Karachi, Sindh, Pakistan.
Transfusion-associated graft-versus-host disease (TA-GVHD) is a fatal complication that occurs in both immunocompromised and immunocompetent individuals following blood transfusion. It is characterised by donor lymphocyte attacks on recipient tissues. We present a case of TA-GVHD in an immunocompetent man in his 70s who developed fever, diarrhoea, rash and pancytopenia after non-irradiated blood transfusion from an unrelated donor.
View Article and Find Full Text PDFRecent advances in hepatitis E virus research and the Japanese clinical practice guidelines for hepatitis E virus infection.
Hepatol Res
August 2024
Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
Acute hepatitis E was considered rare until reports emerged affirming the existence of hepatitis E virus (HEV) genotypes 3 and 4 infections in Japan in the early 2000s. Extensive studies by Japanese researchers have highlighted the pivotal role of pigs and wild animals, such as wild boars and deer, as reservoirs for HEV, linking them to zoonotic infections in Japan. Currently, when hepatitis occurs subsequent to the consumption of undercooked or grilled pork, wild boar meat, or offal (including pig liver and intestines), HEV infection should be considered.
View Article and Find Full Text PDFInsight on the hepatitis B virus and host immune mechanisms in the context of occult hepatitis.
Egypt J Immunol
January 2024
General Medicine Practice Program, Department of Physiology, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
Hepatitis B virus infection is the 10th leading cause of death around the world. Occult HBV infection (OBI) represents those with a viral load of < 104 IU/ml. Among permanent blood recipients, OBI appears to be the most common cause of posttransfusion hepatitis.
View Article and Find Full Text PDFAlloimmunization and hyperhemolysis in sickle cell disease.
Hematology Am Soc Hematol Educ Program
December 2023
Université Paris Est Créteil, INSERM U955, IMRB, Créteil, France.
Alloimmunization against red blood cell antigens and delayed hemolytic transfusion reaction (DHTR) are major barriers to transfusion in sickle cell disease (SCD). In SCD, DHTR is a potentially life-threatening. Blood group polymorphism in SCD patients, who are of African ancestry and frequently exposed to antigens they do not carry; an inflammatory clinical state; and occasional transfusion in acute situations are risk factors for alloimmunization and DHTR.
View Article and Find Full Text PDFStudy protocol of the WashT Trial: transfusion with washed versus unwashed red blood cells to reduce morbidity and mortality in infants born less than 28 weeks' gestation - a multicentre, blinded, parallel group, randomised controlled trial.
BMJ Open
July 2023
College of Medicine and Public Health, Flinders University, Adelaide, South Australia, Australia.
Article Synopsis
- * The study aims to compare the outcomes of washed versus unwashed red blood cells in these infants, focusing on reducing complications and improving overall health post-transfusion.
- * A large-scale trial will involve over 1,100 infants and assess various health outcomes and cost-effectiveness related to the type of blood transfusion received.
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