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The Potency of Cytotoxic Mechanisms of Local Anesthetics in Human Chondrocyte Cells.
Int J Mol Sci
December 2024
Department of Biochemistry, National Defense Medical Center, Taipei 114, Taiwan.
Local anesthetics are commonly used in various clinical settings for both prevention and symptom relief. Numerous clinical studies have demonstrated that intra-articular injections of local anesthetics achieve high success rates in orthopedic practices. However, several widely used local anesthetics, including bupivacaine, lidocaine, and ropivacaine, have been shown to exhibit toxicity to chondrocytes, with the underlying mechanisms of chondrotoxicity remaining poorly understood.
View Article and Find Full Text PDFHydrogel doped with sinomenine-CeO nanoparticles for sustained intra-articular therapy in knee osteoarthritis.
J Drug Target
January 2025
Department of Clinical Laboratory, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing, China.
In this study, we developed an intra-articular injectable hydrogel drug depot (SMN-CeO@G) for sustained OA treatment. This hydrogel system, which carries sinomenine-loaded cerium dioxide nanoparticles (SMN-CeO), enhances anti-inflammatory and anti-apoptotic effects within the joint cavity. SMN-CeO@G features a three-dimensional network structure with an approximate pore size of 10 μm, stably encapsulating SMN-CeO nanoparticles (∼75 nm).
View Article and Find Full Text PDFInnovations in aggregation-induced emission materials for theranostics in the musculoskeletal system.
Biosens Bioelectron
March 2025
Department of Sports Medicine, Huashan Hospital, Fudan University, No.12 Urumqi Middle Rd., Shanghai, 200040, China. Electronic address:
Aggregation-induced emission (AIE) offers a promising solution for achieving lower background and more reliable signals in biomedical imaging. AIE materials also exhibiting photostability and resistance to photobleaching. These characters are crucial for monitoring musculoskeletal functions and offering targeted therapies for related diseases.
View Article and Find Full Text PDFOzone therapy for knee osteoarthritis: a literature visualization analysis of research hotspots and prospects.
Med Gas Res
December 2024
Department of Knee Preservation Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China.
Medical ozone is a molecule composed of three oxygen atoms with anti-inflammatory, analgesic, and antioxidant functions. Ozone therapy (O3 or O2- O3) for knee osteoarthritis has gradually received increasing attention from researchers in recent years. Here, we discuss the research hotspots and development trends of ozone therapy for knee osteoarthritis through literature visualization and analysis.
View Article and Find Full Text PDFLubricating and Dual-Responsive Injectable Hydrogels Formulated From ZIF-8 Facilitate Osteoarthritis Treatment by Remodeling the Microenvironment.
Small
November 2024
Department of Sports Medicine, The First Affiliated Hospital, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Guangdong Provincial Key Laboratory of Speed Capability, Jinan University, Guangzhou, 510630, P. R. China.
Osteoarthritis (OA) is a progressively developing condition primarily characterized by the deterioration of articular cartilage and the proliferation of bone, along with ongoing inflammation. Although the precise pathogenesis remains somewhat elusive, restoring the homeostatic balance of the intra-articular microenvironment is crucial for the management of OA. Intra-articular injection of medication is one of the most direct and effective treatment methods; however, most injectable drugs used for osteoarthritis treatment, due to their rapid breakdown, quick release, poor biological activity, and frequent injections, leading to increased risk of infection and suboptimal therapeutic outcomes.
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