A conceptual model of the Yersinia pestis Ca(2+)-dependence mechanism is proposed. The model is based on data from analyses of peculiarities of recombinant cells of this plague-causing agent carrying the cloned first Bg/II fragment of the Ca(2+)-dependence plasmid (pCaD) and a combination of this fragment and other plasmid pCaD fragments. The data obtained also allowed a revision of the role of the lcr GVH locus of pCaD in this phenomenon.
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