[Local cerebral ischemia in rats induced by ligation of the middle cerebral artery].

A model of local cerebral ischemia induced by ligation of the middle cerebral artery, which is a modification of the techniques proposed by A. Tamura and others, is suggested. It allows experiments to be conducted on conscious animals with appraisal of the morpho-functional state of the nervous system. Ligation of the middle cerebral artery caused a marked decrease (by 85 +/- 9%) in the blood flow in the temporal area of the cerebral cortex. The use of this method will promote a purposeful search for drugs for the treatment of patients with ischemic disorders of cerebral circulation.