The acute tetrachlormethane intoxication leads to structural and metabolic alterations in the rat liver. Morphological changes include centrolobular necroses and blood stasis in dilated sinusoidal capillaries. Metabolic changes are manifested by an increase in the water content and time of the spin-lattice (T1) and spin-spin (T2) relaxation (this indicates a lesser degree of water structuralization and its enhanced lability), and distortion of the correlation between T1 and T2. The prophylactic administration of one of the antihypoxants, antioxidants or actoprotectors normalizes the morphofunctional condition of the liver. According to the degree of the therapeutic efficacy, the examined preparations form the following series: dibunol > gamma-sodium hydroxybutyrate > tomerzol.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Hyperbaric Oxygen Therapy Improves Motor Symptoms, Sleep, and Cognitive Dysfunctions in Parkinson's Disease.
Dement Geriatr Cogn Disord
November 2024
Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Tongji University School of Medicine, Shanghai, China.
Introduction: The aim of the study was to systematically analyze the therapeutic effectiveness of hyperbaric oxygen therapy compared with conventional drug therapy in patients with Parkinson's disease.
Methods: PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang Database searched to the end of March 2023. Two authors independently screened and abstracted data from each trial.
Discovery of the synergy between sulindac and NO expands the application of NSAIDs in cardiac complications.
Bioorg Med Chem
December 2024
Pharmaceutical Research Center and School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, PR China; Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research, Southeast University, Nanjing 211189, PR China. Electronic address:
Cardiac inflammation, a pathological cornerstone in cardiac dysfunction, triggers diastolic impairment, leading to profound myocardial hypoxia. This hypoxic state serves as a potent stimulus for the amplification of inflammatory mediator release, ultimately limiting the therapeutic potential of monotherapies. To address this challenge, compounds that integrate non-steroidal anti-inflammatory drugs (NSAIDs) with nitric oxide (NO) donors was synthesized.
View Article and Find Full Text PDFSodium Hydrosulfide Protects Rats from Hypobaric-Hypoxia-Induced Acute Lung Injury.
Int J Mol Sci
October 2024
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing 100850, China.
Hydrogen sulfide (HS), as a key gas signaling molecule, plays an important role in regulating various diseases, with appropriate concentrations providing antioxidative, anti-inflammatory, and anti-apoptotic effects. The specific role of HS in acute hypoxic injury remains to be clarified. This study focuses on the HS donor sodium hydrosulfide (NaHS) and explores its protective effects and mechanisms against acute hypoxic lung injury.
View Article and Find Full Text PDFCatalase: A Potential Pharmacologic Target for Hydrogen Peroxide in the Treatment of COVID-19.
Curr Top Med Chem
October 2024
Department of Neuropharmacology, Institute of Experimental Medicine, Saint Petersburg, Russia.
Background: Acute respiratory distress syndrome in the elderly with COVID-19 complicated by airway obstruction with sputum and mucus, and cases of asphyxia with blood, serous fluid, pus, or meconium in newborns and people of different ages can sometimes cause hypoxemia and death from hypoxic damage to brain cells, because the medical standard does not include intrapulmonary injections of oxygen-producing solutions. The physical-chemical repurposing of hydrogen peroxide from an antiseptic to an oxygen-producing antihypoxant offers hope for the development of new drugs.
Methods: This manuscript is a meta-analysis performed according to PRISMA guidelines.
The Anti-Hypoxic Mechanism of Sesamoside Determined Using Network Pharmacology.
Dose Response
September 2024
Nursing Department, Affiliated Hospital of Xizang Minzu University, Xianyang, China.
Article Synopsis
- This study investigates how sesamoside, an active compound, helps combat hypoxia using network pharmacology to identify its interactions and mechanisms.
- Researchers collected hypoxia-related targets from databases and built protein-protein interaction networks to analyze biological processes and pathways affected by sesamoside.
- Results show that sesamoside enhances the expression of a key protein, AKR1B1 (AR), and reduces inflammation in hypoxic conditions, suggesting its potential in treating hypoxic diseases.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!