The hypobaric chamber is designed as a teaching aid in providing orientation for some of the physiological stresses in flight. Reactions during chamber training vary from mild ear block to neurocirculatory collapse. This is a retrospective study on reactions from 1986-94 in the hypobaric chamber training unit at King Hussien Medical Centre in Jordan; 39 cases were reported among 705 trainees in a 12-person rectangular hypobaric chamber. We analyzed the various reactions according to type, severity and altitude of occurrence. The most common reactions were found to be ear block (65%) and sinus block (25%). These were treated on the spot and followed for 48 h without sequelae. We did not have any moderate or severe reaction; we found that all reactions were minor, which reflects the efficacy of safety measures taken prior to and during training.
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J Orthop Surg Res
December 2024
Department of Orthopaedic Trauma, Hebei Medical University Third Hospital, Ziqiang Road No.139, Shijiazhuang, Hebei Province, 050051, China.
Background: Posttraumatic osteoarthritis (PTOA) is directly associated with early acute articular cartilage injury. Inhibition of cartilage destruction immediately following joint damage can effectively slow or prevent PTOA progression. Therefore, we sought to determine intervention targets and therapeutic strategies in the acute stage of cartilage injury.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
October 2024
Qinghai University Xining 810001, China Research Center for High Altitude Medicine, Medical College, Qinghai University Xining 810001, China.
This study aims to investigate the effect of Zhishi Xiebai Guizhi Decoction on the phenotypic transformation of pulmonary artery smooth muscle cells(PASMCs) in rats with hypoxic pulmonary hypertension(HPH). Healthy SPF SD rats were randomly assigned to five groups: control group, hypoxia model group, hypoxia + low-dose Zhishi Xiebai Guizhi Decoction group(440 mg·kg~(-1)·d~(-1)), hypoxia + high-dose Zhishi Xiebai Guizhi Decoction group(880 mg·kg~(-1)·d~(-1)), and hypoxia + sildenafil group(30 mg·kg~(-1)·d~(-1)), with right rats in each group. Rats in the hypoxia model and hypoxia + drug groups were exposed to a hypobaric oxygen chamber with a simulated altitude of 5 000 m to induce the PH model.
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November 2024
Respiratory and Critical Care Medicine Center, Traditional Chinese Medicine Hospital of Meishan, Meishan, China.
Background: High altitude cerebral edema (HACE) is a condition where the central nervous system experiences severe impairment as a result of sudden oxygen deprivation at high elevations. At present, effective measures for preventing and treating this condition are still lacking. Eleutheroside B (EB), the primary natural active compound found in the , has demonstrated various biological functions.
View Article and Find Full Text PDFDiabetologia
January 2025
Faculty of Health and Medical Science, University of Surrey, Guildford, UK.
Antioxidants (Basel)
October 2024
High Altitude Medicine Research Center (CEIMA), Arturo Prat University, Iquique 1100000, Chile.
Unlabelled: In Chile, individuals are commonly exposed to high altitude due to the work shift system, involving days of exposure to high altitude followed by days at sea level over the long term, which can result in chronic intermittent hypobaric hypoxia (CIHH). CIHH can cause high-altitude pulmonary hypertension (HAPH), the principal manifestation of which is right ventricular hypertrophy (RVH), in some cases leading to heart failure and eventually death. Studies have shown the contribution of oxidative stress and inflammation to RVH development.
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