The molecular structure of free radicals formed in certain gamma-irradiated steroid hormones and cholesterol determined by electron spin resonance (ESR) and electron nuclear double resonance studies has been reviewed. The influence of intermolecular interactions and hydrogen bonds on the structure of the radicals formed, as well as the effect of substitution of hydroxyl group on the alpha-hyperfine splitting tensor have also been analyzed.
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http://dx.doi.org/10.1016/s0969-8043(96)00234-5 | DOI Listing |
Int J Mol Sci
October 2024
Institute of Crop and Nuclear Technology Utilization, Zhejiang Academy of Agricultural Sciences, 198 Shi-Qiao Road, Hangzhou 310021, China.
Gamma irradiation-based mutant creation is one of the most important methods for rice plant mutagenesis breeding and molecular biology research. Although median lethal dose irradiation severely damages rice seedlings, applying brassinolide (BR) can increase the survival rate of irradiated seedlings. In this study, we investigated the effects of soaking seeds in solutions containing different BR concentrations (0.
View Article and Find Full Text PDFBackground: Blood collection from donors on testosterone therapy (TT) is restricted to red blood cell (RBC) concentrates to avoid patient exposure to supraphysiological testosterone (T). The objective of this study was to identify TT-related changes in RBC characteristics relevant to transfusion effectiveness in patients.
Study Design: This was a two-part study with cohorts of patients and blood donors on TT.
Food Chem Toxicol
February 2023
Radiation Biology Research, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt. Electronic address:
Unlabelled: The endoplasmic reticulum (ER) controls many biological functions besides maintaining the function of liver cells. Various studies reported the role of the ER stress and UPR signaling pathway in various liver diseases via triggering hepatocytes apoptosis. This study aims to investigate the suppressive effect of β-sitosterol (βS) on apoptosis associated with liver injury and ER stress.
View Article and Find Full Text PDFAstrobiology
June 2022
Centro de Astrobiologia (CSIC-INTA), Torrejon de Ardoz, Spain.
The NASA/ESA Mars Sample Return (MSR) Campaign seeks to establish whether life on Mars existed where and when environmental conditions allowed. Laboratory measurements on the returned samples are useful if what is measured is evidence of phenomena on Mars rather than of the effects of sterilization conditions. This report establishes that there are categories of measurements that can be fruitful despite sample sterilization and other categories that cannot.
View Article and Find Full Text PDFMol Med Rep
June 2021
Department of Radiological Science, Konyang University, Daejeon 35365, Republic of Korea.
Prednisolone is an anti‑inflammatory drug used to treat a number of conditions, including liver disease and cancer. Numerous studies have demonstrated that glucocorticoids such as prednisolone modified by ionizing radiation can promote anticancer activity in cancer cells. To the best of our knowledge, however, the effect of ionizing radiation on prednisolone structure and cancer cells has not yet been identified.
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