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Let It Grow: The Role of Growth Factors in Managing Chemotherapy-Induced Cytopenia.
Curr Oncol
December 2024
Department of Hematology, Stem Cell Transplant and Cellular Therapy, Oncology Centre, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia.
Chemotherapy-induced cytopenia (CIC) is characterized by neutropenia, anemia, and thrombocytopenia, which are common and serious complications in cancer treatment. These conditions affect approximately 60% of patients undergoing chemotherapy and can significantly impact quality of life, treatment continuity, and overall survival. The use of growth factors, including granulocyte colony-stimulating factors (GCSFs), erythropoietin-stimulating agents (ESAs), and thrombopoietin receptor agonists (TPO-RAs), has emerged as a promising strategy for managing CIC.
View Article and Find Full Text PDFGuided monocyte fate to FRβ/CD163 S1 macrophage antagonises atopic dermatitis via fibroblastic matrices in mouse hypodermis.
Cell Mol Life Sci
December 2024
Department of Stem Cell Therapy Science, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan.
Macrophages are versatile myeloid leukocytes with flexible cellular states to perform diverse tissue functions beyond immunity. This plasticity is however often hijacked by diseases to promote pathology. Scanning kinetics of macrophage states by single-cell transcriptomics and flow cytometry, we observed atopic dermatitis drastically exhausted a resident subtype S1.
View Article and Find Full Text PDFPredicting apheresis yield and factors affecting peripheral blood stem cell harvesting using a machine learning model.
J Int Med Res
December 2024
Department of Hematology, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China.
Objective: Mobilization and collection of peripheral blood stem cells (PBSCs) are time-intensive and costly. Excessive apheresis sessions can cause physical discomfort for donors and increase the costs associated with collection. Therefore, it is essential to identify key predictive factors for successful harvests to minimize the need for multiple apheresis procedures.
View Article and Find Full Text PDFPolarization and Characterization of M1 and M2 Human Monocyte-Derived Macrophages on Implant Surfaces.
J Vis Exp
December 2024
Department of Medical Materials Science & Technology, Institute for Biomedical Engineering, University Hospital Tübingen;
Foreign body reaction (FBR), an immune-mediated complex healing process, plays a crucial role in integrating implants into the body. Macrophages, as the first line of immune system interaction with implant surfaces, play a bidirectional role in modulating the inflammation-regeneration balance. For a deep understanding and the evaluation of the reactions between implant materials and immune responses, reliable in vitro methods and protocols are pivotal.
View Article and Find Full Text PDFGranulocyte colony-stimulating factor promotes regeneration of severed facial nerve in rats.
Front Neurosci
December 2024
Department of Otorhinolaryngology and Head and Neck Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Background And Aim: The administration of growth and neurotrophic factors has been attempted experimentally as a new therapeutic strategy for severe facial paralysis. Granulocyte colony-stimulating factor (G-CSF) has an effect on the treatment of central nervous system injuries, such as cerebral infarction and spinal cord injury. This study aimed at examining the effects of G-CSF on facial nerve regeneration in rats.
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