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Involving national stakeholders in a systems approach to map drivers of childhood obesity and actions to prevent childhood obesity in Denmark: the Generation Healthy Kids Study.
Health Res Policy Syst
January 2025
Center for Clinical Research and Prevention, Health Promotion and Prevention, Frederiksberg Hospital, Frederiksberg, Denmark.
Background: Childhood obesity is a preventable global public health challenge, increasingly recognized as a complex problem, stemming from complex drivers. Obesity is characterized by multiple interdependencies and diverse influences at different societal levels. Tackling childhood obesity calls for a holistic approach that engages with complexity and recognizes that there is no single "magic bullet" intervention to prevent obesity.
View Article and Find Full Text PDFHarnessing the Sulfur-for-Oxygen Shift: A Magic Bullet for Dynamic Photophysical and Anticancer Activities of Indole-Barbituric Acid Construct.
ChemMedChem
January 2025
Laboratory of Chemical Biology and Medicinal Chemistry, Department of Chemistry, Indian Institute of Technology Roorkee, Uttarakhand, 247667, India.
The development of small molecule-based drugs emerged as a cornerstone of modern drug discovery. Structural activity relationship (SAR) studies in medicinal chemistry are crucial for lead optimization, where a subtle change in the substituent can significantly alter its binding affinity with the biological target. Herein, a highly efficient single-atom substitution (SAS) approach has been developed, where sulfur for oxygen strategy is utilized as a powerful molecular editing technique to identify N-vinyl Indole-thiobarbituric acid (6 a) as a novel small molecule-based scaffold with tunable photophysical and antiproliferative activities.
View Article and Find Full Text PDFIn Vitro Antimicrobial Efficacy Assessment of Ethanolic, Aqueous, and Dual Solvent Extracts of Mushroom : Genomic and Morphological Analysis.
Antibiotics (Basel)
November 2024
Department of Biological Sciences, Winston Salem State University, Winston-Salem, NC 27110, USA.
Infectious diseases caused by bacteria are life-threating and are among the major causes of death in the world. Antibiotics have offered humans a new approach to infection control. Antibiotics are reckoned as the "magic bullets" for the fight against bacterial infections, therefore increasing life expectancy and decreasing mortality and morbidity.
View Article and Find Full Text PDFUltrasound in Shock: Is It the Elusive Magic Bullet?
Indian J Crit Care Med
December 2024
Department of Critical Care Medicine, Manipal Hospital, Dwarka, New Delhi, India.
Kannamani B, Srinivasan S. Ultrasound in Shock: Is It the Elusive Magic Bullet? Indian J Crit Care Med 2024;28(12):1091-1092.
View Article and Find Full Text PDFEditorial: The magic bullet evolution in tumor therapy: novel drug conjugates for targeted delivery.
Front Pharmacol
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