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miR-199a-3p mitigates simulated microgravity-induced cardiac remodeling by targeting MEF2C.
FASEB J
January 2025
National Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, China.
Microgravity-induced cardiac remodeling and dysfunction present significant challenges to long-term spaceflight, highlighting the urgent need to elucidate the underlying molecular mechanisms and develop precise countermeasures. Previous studies have outlined the important role of miRNAs in cardiovascular disease progression, with miR-199a-3p playing a crucial role in myocardial injury repair and the maintenance of cardiac function. However, the specific role and expression pattern of miR-199a-3p in microgravity-induced cardiac remodeling remain unclear.
View Article and Find Full Text PDFUniaxial compressive damage evolution and constitutive modeling of fissure-like rocks under different loading rates based on acoustic emission.
Sci Rep
January 2025
School of Resource, Environment and Safety Engineering, Hunan University of Science and Technology, Xiangtan, 411201, China.
In natural environments, most rocks possess internal fissures and are often exposed to diverse external loads arising from engineering activities and ground stress, among other factors. This study aims to explore the influence of different loading rates on the mechanical properties and acoustic emission (AE) characteristics of fissured rocks and to develop an intrinsic damage model. To achieve this, prefabricated fissured rock specimens that mimic natural rocks were prepared.
View Article and Find Full Text PDFEquity analysis of bus network balance from the perspective of spatial morphology and service capability.
Sci Rep
January 2025
College of Computer & Information Engineering, Xiamen University of Technology, Xiamen, 361024, China.
A balanced and equitable bus network layout plays a crucial role in the efficient operation of cities. The layout of urban bus networks is influenced by various factors, including urban planning, population size, industrial distribution, and road network layout. Forming a comprehensive indicator system and analyzing the balance and fairness of bus network layouts are key research areas.
View Article and Find Full Text PDFFabrication of composite ceramic polymeric membranes for agricultural wastewater treatment.
Sci Rep
January 2025
Chemical Engineering and Pilot Plant Department, Engineering & Renewable Energy Research Institute, National Research Centre (NRC), Giza, 12622, Egypt.
Humans have contaminated water supplies with harmful compounds, including different heavy metals. Heavy metals can interfere with human and animal vital organs and metabolic processes. They are also persistent and bioaccumulative.
View Article and Find Full Text PDFMechanical and microscopic characterization of expansive soils modified by water-soluble polymers.
Sci Rep
January 2025
School of Civil Engineering, Architecture and Environment, Hubei University of Technology, Wuhan, 430068, China.
With the advancement of ecological and environmental protection construction, the research on the modification of expansive soil using environmentally friendly polymers can make up for the harm to the ecological environment caused by traditional modification. Mechanical and microscopic properties of modified expansive soils were analyzed through indoor tests. The results showed that the liquid limit and plasticity index decreased by 52.
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