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Multifunctional Mycobacterial Topoisomerases with Distinctive Features.
ACS Infect Dis
January 2025
Department of Microbiology and Cell Biology, Indian Institute of Science, C.V. Raman Avenue, Bangalore 560012, India.
Tuberculosis (TB) continues to be a major cause of death worldwide despite having an effective combinatorial therapeutic regimen and vaccine. Being one of the most successful human pathogens, retains the ability to adapt to diverse intracellular and extracellular environments encountered by it during infection, persistence, and transmission. Designing and developing new therapeutic strategies to counter the emergence of multidrug-resistant and extensively drug-resistant TB remains a major task.
View Article and Find Full Text PDFDisseminated infection in an immunocompromised adult: An uncommon etiology of skin infection.
IDCases
December 2024
Department of Medicine, Mary Washington Healthcare, Fredericksburg, VA, USA.
is a rapidly growing nontuberculous mycobacterium (NTM) that is ubiquitous in the environment and is associated with skin and soft tissue infections (1). Because is an opportunistic infection, it can present as skin abscess, cellulitis, osteomyelitis, pulmonary infection or disseminated infections, particularly in individuals with compromised immune systems or underlying lung conditions such as cystic fibrosis or bronchiectasis. is one of the most pathogenic rapidly growing mycobacteria (RGM).
View Article and Find Full Text PDFMixed nontuberculous mycobacteria in an immunocompromised patient with probable progressive multifocal leukoencephalopathy.
IJID Reg
March 2025
SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Human Genetics, Stellenbosch University, Cape Town, South Africa.
Objectives: Nontuberculous mycobacteria (NTM) are increasingly recognized opportunistic pathogens found ubiquitously in the environment. The presence of multiple NTM species at the site of disease complicates diagnosis and treatment.
Case And Management: A 40-year-old patient who tested positive for HIV, with an absolute clusters of differentiation 4+ T-cell count of 3 cells/µl and cryptococcaemia, presented with hemoptysis, productive cough, and weight loss.
A cationic main-chain poly(carbonate-imidazolium) potent against Mycobacterium abscessus and other resistant bacteria in mice.
Biomaterials
May 2025
Lee Kong Chian School of Medicine, Nanyang Technological University, 636921, Singapore; Singapore Centre for Environmental Life Sciences Engineering (SCELSE), Nanyang Technological University, 637551, Singapore; National Center for Infectious Diseases (NCID), 308442, Singapore. Electronic address:
The incidence of serious lung infections due to Mycobacterium abscessus, a worrying non-tuberculosis mycobacteria (NTM) species, is rising and has in some countries surpassed tuberculosis. NTM are ubiquitous in the environment and can cause serious lung infections in people who are immunocompromised or have pre-existing lung conditions. M.
View Article and Find Full Text PDFFirst recorded isolation of in a nonendemic setting.
Radiol Case Rep
February 2025
Ministry of Health, Preventive Medicine Department, Nablus, Palestine.
Nontuberculous mycobacteria (NTM) are a diverse group of environmental mycobacteria found ubiquitously in soil and water, causing infections that typically arise from environmental exposure rather than person-to-person transmission. This case report documents the first known detection of in our region, emphasizing the clinical challenges and diagnostic complexities associated with NTM infections. The case involves a 37-year-old male with a significant smoking history who presented with progressively worsening cough, significant weight loss, and bilateral cavitary lung lesions.
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