The effect of reduced glutathione (GSH) and S-acetylglutathione (S-acglu) treatment on several tumor cell lines and normal cells in vitro was investigated. GSH and S-acglu applied at concentrations of 1 mM and 2 mM induced apoptosis in malignant cells as shown by DNA-fragmentation and staining of apoptotic cells with 7-amino-actinomycin D while viability and growth of normal cells were not significantly influenced by this treatment. The results demonstrated that GSH and S-acglu may be selective inducers of apoptosis in malignant cells.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0304-3835(96)04461-8 | DOI Listing |
Publication Analysis
Top Keywords
reduced glutathione
8
normal cells
8
gsh s-acglu
8
apoptosis malignant
8
malignant cells
8
cells
5
glutathione s-acetylglutathione
4
s-acetylglutathione selective
4
selective apoptosis-inducing
4
apoptosis-inducing agents
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!