AI Article Synopsis
- A 43-year-old man with a long-standing history of Crohn's disease developed serum sickness, acute lobular panniculitis, and vasculitis shortly after starting 6-mercaptopurine treatment.
- He presented symptoms such as severe joint pain, protein in urine, fever, rash, and general malaise.
- This type of adverse drug reaction linked to 6-mercaptopurine has not been previously documented.
Article Abstract
A 43-year-old man with a 19-year history of Crohn's disease experienced serum sickness with acute lobular panniculitis and vasculitis within 2 weeks of initiating 6-mercaptopurine therapy. He had no history of extraintestinal manifestations of Crohn's disease or drug allergy. Symptoms included disabling joint pain, proteinuria, fever, rash, and malaise. To our knowledge, this adverse drug reaction has not been described in association with 6-mercaptopurine.
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