Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0006-291x(77)80024-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
()-2-Benzylidenecyclanones: Part XX-Reaction of Cyclic Chalcone Analogs with Cellular Thiols: Unexpected Increased Reactivity of 4-Chromanone- Compared to 1-Tetralone Analogs in Thia-Michael Reactions.
Molecules
November 2024
Institute of Pharmaceutical Chemistry, University of Pécs, H-7624 Pécs, Hungary.
In vitro relative cytotoxicity (IC ()/IC () of ()-3-(4'-methylbenzylidene)-4-chromanone () towards human Molt 4/C8 and CEM T-lymphocytes showed a >50-fold increase in comparison to those of the respective tetralone derivative (). On the other hand, such an increase was not observed in the analogous 4-OCH ( and ) derivatives. In order to study whether thiol reactivity-as a possible basis of the mechanism of action-correlates with the observed cytotoxicities, the kinetics of the non-enzyme catalyzed reactions with reduced glutathione (GSH) and N-acetylcysteine (NAC) of and were investigated.
View Article and Find Full Text PDFStereochemistry in the disorder-order continuum of protein interactions.
Nature
December 2024
REPIN, Department of Biology, University of Copenhagen, Copenhagen N, Denmark.
Intrinsically disordered proteins can bind via the formation of highly disordered protein complexes without the formation of three-dimensional structure. Most naturally occurring proteins are levorotatory (L)-that is, made up only of L-amino acids-imprinting molecular structure and communication with stereochemistry. By contrast, their mirror-image dextrorotatory (D)-amino acids are rare in nature.
View Article and Find Full Text PDFToxic, radioactive, and disordered: a total scattering study of TlTcO.
Phys Chem Chem Phys
December 2024
School of Chemistry, The University of Sydney, Sydney, New South Wales 2006, Australia.
Article Synopsis
- A detailed study on TlTcO, a potential nuclear waste matrix, shows a phase transition from orthorhombic to tetragonal below 600 K, consistent with earlier research using X-ray diffraction.
- Observations from neutron powder diffraction revealed anomalies like large atomic displacements at low temperatures and a decrease in Tc-O bond distance with heating, suggesting changes in local structure symmetry.
- Density functional theory supports a monoclinic model for better energy efficiency, indicating that Tl's lone pairs are 'frozen' at low temperatures but become active and cause structural shifts upon heating, affecting the material's overall properties.
Fluorination Affects the Force Sensitivity and Nonequilibrium Dynamics of the Mechanochemical Unzipping of Ladderanes.
J Am Chem Soc
November 2024
Department of Chemistry, Stanford University, Stanford, California 94305, United States.
When multiple reaction steps occur before thermal equilibration, kinetic energy from one reaction step can influence overall product distributions in ways that are not well predicted by transition state theory. An understanding of how the structural features of mechanophores, such as substitutions, affect reactivity, product distribution, and the extent of dynamic effects in the mechanochemical manifolds is necessary for designing chemical reactions and responsive materials. We synthesized two tetrafluorinated [4]-ladderanes with fluorination on different rungs and found that the fluorination pattern influenced the force sensitivity and stereochemical distribution of products in the mechanochemistry of these fluorinated ladderanes.
View Article and Find Full Text PDFResolution and Absolute Configuration of Fargesin Enantiomers.
Chirality
November 2024
Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, São José do Campos, São Paulo, Brazil.
Fargesin is an important bioactive furofuran lignan isolated from different plant species. Despite presenting potent biological activities, its stereochemical characterization has relied mostly on empirical correlations of optical rotation, an approach considered risky that commonly leads to misassignments and error propagation. Additionally, the enantiomeric purity of fargesin isolates used for biological assays has not been previously investigated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!