A hypothesis on the behaviour of DNA molecules during the cell cycle has been put forward using information on the regularities observed in the formation of chromosome aberrations while irradiating different stages of the cell cycle. The relevant statements of the hypothesis are as follows. 1) The cell cycle involves two stages of intermolecular proofs. The first proof occurs before DNA synthesis, the second one before mitosis. 2) The probable mechanism of the proofs is connected with the formation of hybrid DNA molecules. 3) In the case of multistrandedness, the second proof follows a relay-race principle.
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