The following immunohistochemical markers were studied in 5 Merkel cell carcinomas: cytokeratins, epithelial membrane component, neuron-specific enolase, synaptophysin and chromogranin A. High expression of these markers in tumors allows one to consider them as having epithelial origin with neuroendocrine differentiation. Common leucocytic antigen proved to be very useful in differential diagnosis with malignant lymphoma.
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