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Malignant Hyperthermia: A Killer If Ignored.
J Perianesth Nurs
August 2022
Oral and Maxillofacial Surgery Department, Xiangya Stomatology Hospital, Central South University, Changsha, Hunan, China. Electronic address:
Malignant hypothermia (MH) is a potentially fatal hypermetabolic reaction of skeletal muscle. It is an autosomal dominant disorder that generally occurs in people with RYR1, CACNA1S, or STAC3 mutations. And these genetic abnormalities often cause the imperfection of calcium release channels of skeletal muscle.
View Article and Find Full Text PDFMalignant Hyperthermia in Bariatric Surgery: A Case Study With Clinical, Pathophysiological, Biochemical and Biophysical Correlations.
J Med Cases
December 2020
Departamento de Biologia Molecular, CCEN, UFPB, Joao Pessoa, PB, Brazil.
Malignant hyperthermia (MH) is an acute pharmacogenetic disorder, which while uncommon is potentially fatal. MH is a calcium channelopathy of skeletal muscle in which a constant increase of intracytoplasmic Ca concentration occurs causing a change in cellular metabolism. A hypermetabolic state develops when susceptible patients are exposed to halogenated volatile inhalational anesthetic agents and depolarizing muscle relaxants and/or extreme physical activity in hot environments.
View Article and Find Full Text PDFEnd-tidal to Arterial Gradients and Alveolar Deadspace for Anesthetic Agents.
Anesthesiology
September 2020
From the Anaesthesia, Perioperative and Pain Medicine Program, Centre for Integrated Critical Care, University of Melbourne, Melbourne, Australia (P.J.P.) the Department of Anaesthesia, Austin Health, Victoria, Australia (P.J.P.) the Institute for Breathing and Sleep, Victoria, Australia (P.J.P.) the Department of Basic and Applied Medical Sciences, Ghent University, Ghent, Belgium (J.H.) the Department of Anesthesiology, Onze-Lieve-Vrouw (OLV) Hospital, Aalst, Belgium (J.H.) the Department of Clinical Pharmacy, Catharina Hospital, Eindhoven, The Netherlands (R.J.E.G.) the Discipline of Anaesthesiology, Royal Brisbane and Women's Hospital, The University of Queensland, Brisbane, Australia (A.V.Z.) the Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois (A.D.W.).
Background: According to the "three-compartment" model of ventilation-perfusion ((Equation is included in full-text article.)) inequality, increased (Equation is included in full-text article.)scatter in the lung under general anesthesia is reflected in increased alveolar deadspace fraction (VDA/VA) customarily measured using end-tidal to arterial (A-a) partial pressure gradients for carbon dioxide.
View Article and Find Full Text PDFElectroencephalographic assessment of oral meloxicam, topical anaesthetic cream and cautery iron for mitigating acute pain in pigs (Sus scrofa) undergoing tail docking.
Vet Anaesth Analg
September 2017
Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.
Objective: To evaluate the efficacy of oral meloxicam, topical anaesthetic cream and cautery iron in mitigating acute nociceptive responses of pigs to tail docking.
Study Design: A prospective, randomized, controlled experimental study.
Animals: A total of 40 healthy Large WhitexLandrace pigs aged 21±1 days, weighing 6.
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