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Graph pangenome reveals the regulation of malate content in blood-fleshed peach by NAC transcription factors.
Genome Biol
January 2025
College of Agriculture & Biotechnology, Zhejiang University, Hangzhou, 310058, China.
Background: Fruit acidity and color are important quality attributes in peaches. Although there are some exceptions, blood-fleshed peaches typically have a sour taste. However, little is known about the genetic variations linking organic acid and color regulation in peaches.
View Article and Find Full Text PDFSeroepidemiology, molecular detection, and isolation attempts of Toxoplasma gondii in dairy goats from Rio de Janeiro, Brazil.
Vet Res Commun
January 2025
Laboratório de Protozoologia, Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, RJ, Brasil.
Goats are the one of the most susceptible domestic species to toxoplasmosis affecting animal health and production. The present study aimed to determine the seroprevalence of T. gondii infection in dairy goats from Rio de Janeiro, Brazil, as well as to evaluate associated risk factors, parasitic DNA detection in raw goat milk samples, and attempts to isolate the parasite from raw goat milk samples.
View Article and Find Full Text PDFTibial Skeletal Adaptations in Male and Female Marine Corps Officer Candidates Undergoing 10 Weeks of Military Training.
Calcif Tissue Int
January 2025
Neuromuscular Research Laboratory/Warrior Human Performance Research Center, Department of Sports Medicine and Nutrition, University of Pittsburgh, 3860 S. Water St, Pittsburgh, PA, 15203, USA.
Military training improves tibial density, structure, and estimated strength; however, men and women may adapt differently. Most work performed in military populations has assessed changes in bone health during initial entry programs, a timeframe at the beginning of a service member's career when bones may be more adaptable to a novel mechanical stimulus. The purpose of this investigation was to examine changes in tibial volumetric bone mineral density (vBMD), structure, and estimated strength, and biomarkers of bone metabolism (P1NP, osteocalcin, TRAP5b, sclerostin) between male and female candidates measured at the start and end of United States Marine Corps Officer Candidates School (OCS), a 10-week military training program attended by older service members (~ 25 y/o) who may have previous military experience.
View Article and Find Full Text PDFAdministration of Bisphosphonate Preparations to Mice with Mild-type Hypophosphatasia Reduces the Quality of Spontaneous Locomotor Activity.
Calcif Tissue Int
January 2025
Department of Pharmacology, Tokyo Dental College, 2-9-18, Kandamisaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan.
Hypophosphatasia (HPP) is a congenital bone disease caused by tissue-nonspecific mutations in the alkaline phosphatase gene. It is classified into six types: severe perinatal, benign prenatal, infantile, pediatric, adult, and odonto. HPP with femoral hypoplasia on fetal ultrasonography, seizures, or early loss of primary teeth can be easily diagnosed.
View Article and Find Full Text PDFAdvancing brain immunotherapy through functional nanomaterials.
Drug Deliv Transl Res
January 2025
Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, 300044, Hsinchu, Taiwan.
Glioblastoma (GBM), a highly aggressive brain tumor, poses significant treatment challenges due to its highly immunosuppressive microenvironment and the brain immune privilege. Immunotherapy activating the immune system and T lymphocyte infiltration holds great promise against GBM. However, the brain's low immunogenicity and the difficulty of crossing the blood-brain barrier (BBB) hinder therapeutic efficacy.
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