Screening of pharmaceutical agents releasing active nucleases from inactive complexes was performed. Cisplatin and sodium arsenate were shown in vitro to have such properties. Sodium arsenate which is more expedient for the treatment of human patients was studied in vivo. It was administered to albino mice in a dose of 0.2 mg/kg once a day for 6 days. Due to the release, the activity of free serum DNAse and RNAse markedly increased (1.5-2 times). Activation of endogenic nucleases is more promising than the use of exogenic enzymes in complex therapy of viral affections and rickettsiosis.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Metabolomics reveals the potential mechanism of La(III) promoting enrichment of Sodium hydrogen arsenate and Roxarsone in Solanum nigrum L.
Sci Total Environ
November 2024
School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China. Electronic address:
The rare earth element lanthanum (La(III)) has been found to effectively enhance crop yields and improve plant growth and development. Arsenic (As), as a class of toxic metals widely found in the environment, poses a serious threat to both ecological and human health. Research on the application of La(III) in phytoremediation to enhance remediation efficiency is currently lacking.
View Article and Find Full Text PDFPseudochrobactrum asaccharolyticum mitigates arsenic induced oxidative stress of maize plant by enhancing water status and antioxidant defense system.
BMC Plant Biol
September 2024
Faculty of Production and Power Engineering, University of Agriculture in Krakow, Balicka 116B, Krakow, 30-149, Poland.
Article Synopsis
- Oxidative stress from reactive oxygen species (ROS) plays a significant role in arsenic toxicity, negatively impacting plant water absorption and overall health.
- The study investigated the effects of an arsenic-resistant plant growth-promoting rhizobacteria (PGPR), specifically the strain MD3, on maize, aiming to mitigate the harmful effects of arsenic.
- Results showed that maize under high arsenic stress experienced reduced osmotic potential and growth, but the MD3 strain helped counteract these stress effects, enhancing growth and physiological conditions.
24-Epibrassinolide mitigates arsenate stress in seedlings of Oryza sativa (IR-20) via the induction of phenylpropanoid pathway.
Plant Physiol Biochem
October 2024
Department of Biotechnology, School of Bioengineering, SRM Institute of Science and Technology, Kattankulathur, 603 203, Tamil Nadu, India. Electronic address:
The introduction of arsenic, a hazardous metalloid, into the soil system due to heavy industrialization has negatively affected agricultural productivity, resulting in limited crop yields. A recent breakthrough in stress-responsive hormones, specifically brassinosteroids, has extensively covered the role of antioxidant enzyme defense systems in heavy metal stress mitigation. Considering the antioxidant properties and metal complex formation abilities of polyphenols, our study focuses on examining their role in arsenate toxicity amelioration by 24-epibrassinolide.
View Article and Find Full Text PDFSynchrotron tomography of magnetoprimed soybean plant root system architecture grown in arsenic-polluted soil.
Front Plant Sci
July 2024
Department of Plant Physiology, Faculty of Agrobiology and Food Resource, Slovak University of Agriculture, Nitra, Slovakia.
The present study evaluated the repercussions of magnetopriming on the root system architecture of soybean plants subjected to arsenic toxicity using synchrotron radiation source based micro-computed tomography (SR-µCT). This will be used evey where as abbreviation for the technique for three-dimensional imaging. Seeds of soybean were exposed to the static magnetic field (SMF) of strength (200 mT) for 1h prior to sowing.
View Article and Find Full Text PDFEffects of developmental exposure to arsenic species on behavioral stress responses in larval zebrafish and implications for stress-related disorders.
Toxicol Sci
September 2024
Department of Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, United States.
Arsenic (As) is globally detected in drinking water and food products at levels repeatedly surpassing regulatory thresholds. Several neurological and mental health risks linked to arsenic exposure are proposed; however, the nature of these effects and their association with the chemical forms of arsenic are not fully understood. Gaining a clear understanding of the etiologies and characteristics of these effects is crucial, particularly in association with developmental exposures where the nervous system is most vulnerable.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!