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Impact of Weather and Holidays on Orthopedic Emergency Room Crowding, Fractures, and Polytraumas in a Third-Level Referral Trauma Center in Europe.
Adv Orthop
January 2025
Department of Orthopedics and Trauma Surgery, University of Pisa, Pisa, Italy.
Orthopedic trauma is a significant component of emergency department workloads worldwide. The relationship between weather conditions and injury rates is controversial in modern literature. Even less has been written to investigate bank holidays' influence on contusions, dislocations, fractures, and even polytrauma.
View Article and Find Full Text PDFRadiological characteristics of the knee in young patients with medial meniscus horizontal tears.
J Knee Surg
January 2025
Orthopaedic Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Introduction: We aimed to assess medial meniscal (MM) healing and horizontal tear (HT) repair in the knees of young patients.
Materials And Methods: We enrolled 37 knees of 35 patients (mean age: 28.0 ± 10.
Many options are available concerning the graft fixation in ACL reconstruction, one of them being a suspensory device. Our study aimed to compare the strength of two different devices of fixation (suspensory device vs screw) on the tibia. We enrolled 80 patients older than 18 years with an isolated ACL tear confirmed at the MRI, divided into two comparative groups for a prospective study.
View Article and Find Full Text PDFDistinct Ocular Surface Microbiome in Keratoconus Patients Correlate With Local Immune Dysregulation.
Invest Ophthalmol Vis Sci
January 2025
GROW Research Laboratory, Narayana Netralaya Foundation, Bangalore, India.
Purpose: Keratoconus (KC) is characterized by irregular astigmatism along with corneal stromal weakness and is associated with altered immune status. Tissue resident microbiomes are known to influence the immune status in other organs, but such a nexus has not been described in ocular conditions. Therefore, we examined the ocular surface microbiome of patients with KC and correlated it to the immune cell and tear molecular factor profiles.
View Article and Find Full Text PDFTranscriptomic Profile Analysis of Brain Tissue in the Absence of Functional TRPM8 Calcium Channel.
Biomedicines
December 2024
Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine Peoria, Peoria, IL 61605, USA.
Transient Receptor Potential Melastatin 8 (TRPM8) is a non-selective, Ca-permeable cation channel involved in thermoregulation and other physiological processes, such as basal tear secretion, cell differentiation, and insulin homeostasis. The activation and deactivation of TRPM8 occur through genetic modifications, channel interactions, and signaling cascades. Recent evidence suggests a significant role of TRPM8 in the hypothalamus and amygdala related to pain sensation and sexual behavior.
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