[Neonatal diabetes mellitus associated with an autoimmune disease].

Arch Pediatr

Service de néonatologie-maternité et de réanimation pédiatrique, Brest, France.

Published: August 1996

Background: Insulin-dependent diabetes mellitus can be associated to an auto-immune disease. A similar association may be seen in the neonate.

Case Report: A one-day-old boy was admitted for ketoacidosis due to diabetes mellitus. Investigation showed that he also suffered from an auto-immune enteropathy with several types of autoantibodies, particularly anti-enterocytes antibodies. Immunotherapy was ineffective. Multi-organ lesions developed subsequently, particularly a pulmonary disease responsible for the death at the age of 2 years.

Conclusion: Physiopathology of this association remains unclear and the report of further cases should help improve our knowledge.

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http://dx.doi.org/10.1016/0929-693x(96)82160-9DOI Listing

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