Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0140-6736(05)60878-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Background: In recent years, stroke has become the leading cause of death in the Chinese population，and the burden of stroke is huge. The aim of this study is to describe the epidemiological characteristics of population-based stroke incidence and case fatality rates in China, which are nationally representative.
Methods: In 2013, a nationally representative household survey was conducted at 155 survey sites in 31 provinces.
Targeting allograft inflammatory factor-1 reprograms kidney macrophages to enhance repair.
J Clin Invest
January 2025
Division of Nephrology, Duke University, Durham, United States of America.
The role of macrophages remains incompletely understood in kidney injury and repair. Their plasticity offers an opportunity to polarize them towards mediating injury resolution in both native and transplanted kidneys undergoing ischemia and/or rejection. Here, we show that infiltrating kidney macrophages augmented their AIF-1 expression after injury.
View Article and Find Full Text PDFPulmonary microbiota disruption by respiratory exposure to carbon quantum dots induces neuronal damages in mice.
J Hazard Mater
January 2025
Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, Nanjing 210009, China; School of Public Health, Southeast University, Nanjing 210009, China; Yancheng Kindergarten Teachers College, Yancheng 224005, China.
Given the fact that carbon quantum dots (CQDs) have been commercially produced in quantities, it is inevitable to make their ways into environment and interact closely with the public. Even though CQDs in the environment have been reported to damage the central nervous system, the underlying mechanisms of neurotoxic effects of CQDs following respiratory exposure is still not clear. Intranasal instilled CQDs, mimicking respiratory exposure, induces neurobehavioral impairments associated with neuronal cell death of ferroptosis and disulfidptosis that is regulated by metabolic reprogramming of glutathione and cysteine pathways in the cortex and hippocampus where CQDs were hardly accumulated.
View Article and Find Full Text PDFTargeting the mitotic kinase NEK2 enhances CDK4/6 inhibitor efficacy by potentiating genome instability.
J Biol Chem
January 2025
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA. Electronic address:
Selective inhibitors that target cyclin dependent kinases 4 and 6 (CDK4/6i) are FDA approved for treatment of a subset of breast cancers and are being evaluated in numerous clinical trials for other cancers. Despite this advance, a subset of tumors are intrinsically resistant to these drugs and acquired resistance is nearly inevitable. Recent mechanistic evidence suggests that in addition to stalling the cell cycle, the anti-tumor effects of CDK4/6i involve the induction of chromosomal instability (CIN).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!