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Bilateral Globus Pallidus Lesions and Delayed Hypoxic Encephalopathy Induced by Overuse of Transdermal Fentanyl Patches.
Cureus
October 2024
Health Science, Fukui Health Science University, Fukui, JPN.
We describe a rare case of bilateral globus pallidus lesions (BPL) and delayed hypoxic encephalopathy (DHE) induced by the overuse of transdermal fentanyl patches. The patient was a 54-year-old woman, who had a history of unexplained, intractable anal pain, for which several medications were prescribed, but with very limited effectiveness. Four days prior to admission, she was newly prescribed transdermal fentanyl patches at a dose of 4 mg/day.
View Article and Find Full Text PDFCan Breaking Heroin Addiction Lead to a Broken Heart? A Case of Reverse Takotsubo Cardiomyopathy in a Patient With Heroin Withdrawal.
Tex Heart Inst J
March 2023
Section of Cardiology, John W. Deming Department of Medicine, Tulane University, New Orleans, Louisiana.
Reverse takotsubo cardiomyopathy is triggered by emotional or physical stress and has a presentation similar to that of acute coronary syndrome. A 39-year-old woman with a history of heroin use disorder presented with intractable nausea, vomiting, and diarrhea. She was diagnosed with heroin withdrawal and started on buprenorphine-naloxone.
View Article and Find Full Text PDFHDAC6 Inhibition Reverses Cisplatin-Induced Mechanical Hypersensitivity via Tonic Delta Opioid Receptor Signaling.
J Neurosci
October 2022
Laboratories of Neuroimmunology, Department of Symptom Research, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030
Peripheral neuropathic pain induced by the chemotherapeutic cisplatin can persist for months to years after treatment. Histone deacetylase 6 (HDAC6) inhibitors have therapeutic potential for cisplatin-induced neuropathic pain since they persistently reverse mechanical hypersensitivity and spontaneous pain in rodent models. Here, we investigated the mechanisms underlying reversal of mechanical hypersensitivity in male and female mice by a 2 week treatment with an HDAC6 inhibitor, administered 3 d after the last dose of cisplatin.
View Article and Find Full Text PDFEffect of Low-Dose Naltrexone on Egyptian Children with Intractable Epilepsy: A Case Series Study.
Neurol India
January 2022
Department of Neurology, Cairo University, Giza, Egypt.
Epilepsy is a chronic neurological disorder affecting 50 million patients worldwide, in need of continuous treatment, while 30% of them are refractory to treatment. Despite multiple antiepileptic drugs are available for the treatment of epilepsy, still refractory epilepsy especially in children represents a social burden in developing countries. Low-dose naltrexone (LDN) has been proposed as an immune modulator in multiple diseases and proved benefit especially in diseases with immune dysregulation.
View Article and Find Full Text PDFIntrathecal Drug Delivery for the Treatment of Cancer-Associated Chronic Pain in Children.
Neuromodulation
August 2023
Anesthesiology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Objectives: Management of refractory cancer-associated pain can be particularly challenging. Regional anesthesia is an alternative modality to treat acute and chronic refractory pain. Intrathecal (IT) drug delivery of opioids and other adjuncts has been used to treat refractory cancer-associated pain.
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