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Associations between 25-hydroxyvitamin D/calcium/alkaline phosphatase levels and the risk of developing kidney stones: Results from NHANES (2013-2018)-based and Mendelian randomization studies.
Medicine (Baltimore)
January 2025
Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
This study explores the relationship between 25-hydroxyvitamin D/calcium/alkaline phosphatase (ALP) levels and kidney stone development via cross-sectional and Mendelian randomization (MR) analyses. We used data from the National Health and Nutrition Examination Survey (NHANES) 2013 to 2018 to explore the associations of 25(OH)D metabolite, calcium, and ALP levels with kidney stone development, LDSC analysis to determine the associations between their genetically predicted levels and kidney stone development, and MR analysis to determine the causality of those relationship via genome-wide association studies (GWASs). The cross-sectional study revealed a relationship between ALP levels and kidney stone development (Model 1: OR = 1.
View Article and Find Full Text PDFPreliminary screening of new biomarkers for sepsis using bioinformatics and experimental validation.
PLoS One
January 2025
Department of Emergency Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, People's Republic of China.
Background: The morbidity and mortality of sepsis remain high, and so far specific diagnostic and therapeutic means are lacking.
Objective: To screen novel biomarkers for sepsis.
Methods: Raw sepsis data were downloaded from the Chinese National Genebank (CNGBdb) and screened for differentially expressed RNAs.
mHealth-Based Diabetes Prevention Program for Chinese Mothers With Abdominal Obesity: Randomized Controlled Trial.
JMIR Mhealth Uhealth
January 2025
Xiangya School of Nursing, Central South University, Changsha, China.
Background: Among people with abdominal obesity, women are more likely to develop diabetes than men. Mobile health (mHealth)-based technologies provide the flexibility and resource-saving opportunities to improve lifestyles in an individualized way. However, mHealth-based diabetes prevention programs tailored for busy mothers with abdominal obesity have not been reported yet.
View Article and Find Full Text PDFBackground: Moral distress is highly prevalent among health care workers in intensive care in which spirituality has been identified both as a risk factor for moral distress and as a resource to mitigate it.
Objectives: Considering these contradictory findings, this study examined why moral distress is perceived in different ways and to what extent spirituality influences the ability to cope with moral distress.
Methods: In a qualitative study in German-speaking countries, semistructured interviews were evaluated using thematic analysis and typology construction according to Stapley et al.
Synthesis and antifungal activity of arecoline derivatives containing amino acid fragments.
Mol Divers
January 2025
School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, China.
A series of new arecoline derivatives containing amino acid fragments were synthesized, and their fungicidal activities were investigated. All synthesized compounds were characterized by H NMR, CNMR, and HRMS. Preliminary bioactivity assays demonstrated that Compounds 3k, 3n, 3p, 3q, 3r, and 3s exhibited significant antifungal activity against Botryosphaeria cactivora, Botryosphaeria dothidea, and Fusarium pseudograminearum at a concentration of 100 μg/mL.
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