Background: Until 1985, volunteer donors provided blood for almost all transfusions and donated blood was rarely restricted for transfusion to a specific patient. With the AIDS (Acquired Immunodeficiency Syndrome) crisis, autologous (blood from oneself) and directed (blood from families and friends) donations increased, calling for handling of far greater complexity. At the University of California at San Francisco Medical Center, the demand for special donations superseded the development of systems to meet the demand and autologous and/or directed donations were often not available when needed. After a rapid rise in incident reports and complaints from physicians, nurses, patients, and families, a quality improvement (QI) team was formed in mid-1991 to improve blood availability.
Method: Meetings were held to analyze the processes involved in blood donation and transfusion, identify and categorize problems, develop interventions, test and implement solutions, and monitor improvements. Educational efforts were implemented throughout the medical center, recruitment for a special donations co-ordinator began, and changes were made in the blood bank's internal systems.
Results: In two years, with stable numbers of transfused units, the number of incident reports regarding blood availability decreased from 19 to 2 per year-an improvement that has been sustained for more than three years. The QI team continues to meet regularly to design and implement additional improvements.
Conclusion: A QI team has improved the availability of autologous and directed-donor blood to patients and has extended the impact of the QI methodology throughout the medical center as a whole.
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http://dx.doi.org/10.1016/s1070-3241(16)30284-x | DOI Listing |
Chimeric antigen receptor (CAR) T-cell products axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel) are approved for relapsed/refractory large B-cell lymphoma (R/R LBCL). Emerging evidence indicates that delayed CAR T-cell infusion, including prolonged time from leukapheresis to infusion, known as vein-to-vein time (V2Vt), may adversely impact clinical outcomes. We conducted a systematic literature review (SLR) and meta-analysis to identify differences in V2Vt in patients with R/R LBCL treated with axi-cel, tisa-cel, or liso-cel.
View Article and Find Full Text PDFBlood Adv
January 2025
Vanderbilt University Medical Center, Nashville, Tennessee, United States.
In plasma, the zymogens factor XII (FXII) and prekallikrein reciprocally convert each other to the proteases FXIIa and plasma kallikrein (PKa). PKa cleaves high-molecular-weight kininogen (HK) to release bradykinin, which contributes to regulation of blood vessel tone and permeability. Plasma FXII is normally in a "closed" conformation that limits activation by PKa.
View Article and Find Full Text PDFCirculation
January 2025
University of Texas Southwestern Medical Center, Dallas (D.K.M, J.A.d.L., J.A.H).
J Med Internet Res
January 2025
International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki, Japan.
Background: Few studies have explored the relationship between macronutrient intake and sleep outcomes using daily data from mobile apps.
Objective: This cross-sectional study aimed to examine the associations between macronutrients, dietary components, and sleep parameters, considering their interdependencies.
Methods: We analyzed data from 4825 users of the Pokémon Sleep and Asken smartphone apps, each used for at least 7 days to record objective sleep parameters and dietary components, respectively.
JMIR Form Res
January 2025
Faculty of Medicine, The University of Queensland, Brisbane, Australia.
Background: Opioid medications are important for pain management, but many patients progress to unsafe medication use. With few personalized and accessible behavioral treatment options to reduce potential opioid-related harm, new and innovative patient-centered approaches are urgently needed to fill this gap.
Objective: This study involved the first phase of co-designing a digital brief intervention to reduce the risk of opioid-related harm by investigating the lived experience of chronic noncancer pain (CNCP) in treatment-seeking patients, with a particular focus on opioid therapy experiences.
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