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Asteroid Saponins: A Review of Their Bioactivity and Selective Cytotoxicity.
Mar Drugs
December 2024
Centre for Bioinnovation, University of the Sunshine Coast, Maroochydore BC, QLD 4558, Australia.
Saponins are a diverse class of secondary metabolites that are often reported to exhibit a variety of pharmacological applications. While research into the elucidation and application of plant and class Holothuroidea-derived saponins (i.e.
View Article and Find Full Text PDFPreparation and characterization of Levan composite film incorporating vanillin for use as a potential edible coating for peony seed oil.
Int J Biol Macromol
February 2025
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, PR China. Electronic address:
The study prepared an edible packaging material for peony seed oil by adding natural antioxidant vanillin to a microbial Levan composite film. The presence of highly branched Levan, containing polyhydroxyl groups, significantly enhanced the maximum tension (26.57 N), tensile strength (36.
View Article and Find Full Text PDFPyroptosis was suppressed by 20-hydroxyecdysone through Lin28b-mediated let-7d in vascular endothelial cells.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Department of Structural Heart Disease, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, P.R. China.
20-hydroxyecdysone (20E), a natural polyhydroxylated steroid, has exhibited anti-inflammatory effects across various diseases. This study investigates the potential connection between 20E's anti-inflammatory properties and the RNA-binding protein Lin28b, which is notably upregulated in TNF-α-stimulated endothelial cells. Herein, we discovered that 20E can selectively downregulate Lin28b expression without affecting its paralog Lin28a.
View Article and Find Full Text PDFExisting Forms of Notoginsenoside R in Rats and Their Potential Bioactivities.
J Agric Food Chem
December 2024
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Article Synopsis
- - Notoginsenoside R (NG-R), a key saponin in a medicinal plant, was analyzed using advanced UHPLC-ESI-Q-TOF-MS/MS techniques to identify its various forms and distribution in rats, resulting in the detection of 105 metabolites, including 89 new ones.
- - The study proposed a new fragmentation pathway for protopanaxatriol (PPT) and revealed novel metabolic reactions for NG-R, such as polyhydroxylation and glucuronidation, with significant metabolite accumulation observed in various organs.
- - Predictive analyses suggested 48 metabolites may have therapeutic effects on three diseases, with follow-up experiments confirming anti-tumor and anti-inflammatory properties in eight specific
(-)-Swainsonine is a polyhydroxylated indolizidine alkaloid with potent inhibitory activity against α-D-mannosidases. In this work, we successfully reconstituted swainsonine biosynthetic pathway both in vivo and in vitro. Our study unveiled a surprising epimerization mechanism involving an imine reductase (SwnN) and two non-heme iron and α-ketoglutarate-dependent oxygenases (SwnH2 and SwnH1).
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