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Treatment-Free Remissions in Children With Chronic Myeloid Leukemia (CML): A Prospective Study From the Tata Memorial Hospital (TMH) Pediatric CML (pCML) Cohort.
Am J Hematol
February 2025
Tata Memorial Hospital, Pediatric Oncology, Mumbai, India.
Pediatric chronic myeloid leukemia (pCML) is a rare childhood malignancy, representing 2%-3% of all childhood leukemia. Tyrosine kinase inhibitors (TKIs) have greatly improved survival but pose challenges due to their long-term effects on growth and bone health in children. We prospectively studied treatment-free remission (TFR) in 45 children with pCML in chronic phase on imatinib.
View Article and Find Full Text PDFAxatilimab: First Approval.
Drugs
November 2024
Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
Article Synopsis
- * In August 2024, Axatilimab received approval in the USA for treating cGVHD in patients who have not responded to at least two prior systemic therapies, applicable to both adults and children over 40 kg.
- * The article reviews the key milestones in the development of Axatilimab leading to its first approval for cGVHD treatment.
The Impact of Surgical Margin in Wide Local Excision of Pediatric Melanoma - An Argument for a More Conservative Approach.
J Pediatr Surg
January 2025
The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA; University of Texas Health Science Center at Houston (UTHealth Houston), 7000 Fannin St, Suite 1706, Houston, TX 77030, USA; UTHealth Houston John P. and Kathrine G. McGovern Medical School, 6431 Fannin St, Houston, TX 77030, USA.
Background: Pediatric melanoma is the most common skin cancer in children. Achieving surgical margins recommended by the National Comprehensive Cancer Network (NCCN) for wide local excision (WLE) is challenging in children with less body domain. This study investigated whether surgical margin impacted postoperative clinical outcomes following WLE for melanoma in children and adolescents.
View Article and Find Full Text PDFPeace, equanimity and acceptance in the cancer experience: validation of the German version (PEACE-G) and associations with mental health, health-related quality of life and psychological constructs.
BMC Psychol
September 2024
Department of Medical Psychology and Medical Sociology, University of Leipzig, Leipzig, Germany.
Background: Systematic reviews and meta-analyses reveal the importance of an accepting attitude towards cancer for mental health and functional coping. The aim of this study was to examine the psychometric properties of the German translation of the Peace, Equanimity, and Acceptance in the Cancer Experience (PEACE) questionnaire (Mack et al., 2008) and to investigate its associations with mental health, health-related quality of life (HRQoL) and related constructs.
View Article and Find Full Text PDFThe landscape of drug sensitivity and resistance in sarcoma.
Cell Stem Cell
October 2024
Department of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, USA. Electronic address:
Article Synopsis
- - Sarcomas are rare tumors with over 100 subtypes, making it challenging to find effective therapies; there's a need for personalized treatment approaches to enhance patient outcomes.
- - Patient-derived tumor organoids (PDTOs) were used to study drug resistance and sensitivity in sarcoma, analyzing 194 specimens from 126 patients across 24 subtypes.
- - The research developed a high-throughput screening method that provided results quickly and showed that drug sensitivity linked to tumor characteristics; 59% of samples matched with at least one effective FDA-approved treatment.
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