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Stuck in the Sump: A Rare Complication of Biliary Surgery.
Cureus
December 2024
Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, USA.
Sump syndrome is a rare complication of biliary surgery that is now rarely seen in the era of Endoscopic Retrograde Cholangiopancreatography (ERCP). It occurs when the distal common bile duct becomes obstructed between an anastomosis from a choledochoduodenostomy (CDD) and the ampulla of Vater, forming a sump that accumulates debris. Sump syndrome should be considered as a diagnosis in patients who present with cholangitis or pancreatitis and any history of biliary diversion, regardless of the time of presentation.
View Article and Find Full Text PDFROBOTIC PANCREATICODUODENECTOMY FOR THE TREATMENT OF A MIXED NEUROENDOCRINE-NON-NEUROENDOCRINE NEOPLASM (MINEN) OF THE AMPULLA OF VATER.
Arq Bras Cir Dig
December 2024
Hospital Moriah, Endoscopy Department - São Paulo (SP), Brazil.
Mixed neuroendocrine-non-neuroendocrine tumors (MiNEN) are a rare type of tumor formed by two components, a non-neuroendocrine component that is most often an adenocarcinoma and a neuroendocrine tumor, and each of these components must represent at least 30% of the tumor. The origin of this tumor on the ampulla of Vater or periampullary region is more infrequent. Usually, the lesions are highly aggressive and quickly metastasizing, and their biological behavior is dictated by the high grade of the neuroendocrine component.
View Article and Find Full Text PDFGangliocytic paragangliomas are benign neuro-endocrine tumors of the ampulla of Vater. Their preoperative diagnosis is hampered by the low yield of biopsies and non-specific imaging. Their management relies then on resection.
View Article and Find Full Text PDFHuntingtin CAG repeat size variations below the Huntington's disease threshold: associations with depression, anxiety and basal ganglia structure.
Eur J Hum Genet
November 2024
Department Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany.
Article Synopsis
- Huntington's disease (HD) is linked to psychiatric symptoms, but the effects of variations in the huntingtin gene (HTT) CAG repeat sizes on psychiatric disorders like major depressive disorder (MDD) and anxiety disorders (ANX) are not well-studied.
- In this study, researchers compared CAG repeat sizes among patients with MDD and ANX to healthy controls, finding that certain repeat ranges did not show an overrepresentation among patients and that age influenced the associations between repeat sizes and psychiatric risks.
- The findings suggest that variations in CAG repeat sizes in the non-HD range can modulate the risk for psychiatric disorders and affect basal ganglia structure, highlighting the potential impact of the normal huntingtin protein
Is pancreaticoduodenectomy justified for metastatic melanoma to the ampulla of Vater?
J Chin Med Assoc
October 2024
Division of General Surgery, Department of Surgery.
Article Synopsis
- Metastatic melanoma of the ampulla of Vater is a rare condition with 14 patient cases analyzed, primarily from cutaneous origins (73%) and presenting with jaundice (86% as a common symptom).
- The median size of the melanoma was 2.75 cm, and most patients (82%) had metastasis to other organs like the brain, lungs, and liver at diagnosis.
- Surgical interventions like pancreaticoduodenectomy, along with chemotherapy, were linked to improved survival rates, highlighting that major surgeries can still be viable options even in metastatic cases.
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