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Background: Antibiotics are commonly used drugs in farm animals for therapeutic, prophylactic and diagnosis purposes. As a result of the use of antibiotics in livestock, residues of antibiotics may be present in animal-derived foods, especially in meat. This study aimed at determining the antibiotic residues in cattle slaughtered at Nekemte municipal abattoir and assessing the knowledge, attitude and practice (KAP) level of the community about antibiotic residue in food of cattle origin.
View Article and Find Full Text PDFEnhancing the antibacterial function of probiotic Nissle: when less is more.
Appl Environ Microbiol
November 2023
Section of Molecular Microbiology, Imperial College London, London, United Kingdom.
Probiotic bacteria confer multiple health benefits, including preventing the growth, colonization, or carriage of harmful bacteria in the gut. Bacteriocins are antibacterial peptides produced by diverse bacteria, and their production is tightly regulated and coordinated at the transcriptional level. A popular strategy for enhancing the antibacterial properties of probiotic bacteria is to retrofit them with the ability to overproduce heterologous bacteriocins.
View Article and Find Full Text PDFAn Integrated Strategy for Investigating Antioxidants from Royle ex Decne and Their Potential Target Proteins.
Antioxidants (Basel)
March 2023
Wuxi School of Medicine, Jiangnan University, Wuxi 214122, China.
Natural products have been used extensively around the world for many years as therapeutic, prophylactic, and health-promotive agents. Royle ex Decne, a plant used in traditional Tibetan medicine, has been demonstrated to have significant antioxidant and anti-inflammatory properties. However, the material basis of its medicinal effects has not been sufficiently explored.
View Article and Find Full Text PDFProtective role of engineered extracellular vesicles loaded quercetin nanoparticles as anti-viral therapy against SARS-CoV-2 infection: A prospective review.
Front Immunol
December 2022
Department of Anatomy and Cell Biology, College of Medicine, Gachon University, Incheon, South Korea.
Quercetin (QCT) is a naturally occurring phenolic flavonoid compound with inbuilt characteristics of antioxidant, anti-inflammatory, and immune protection. Several recent studies have shown that QCT and QCTits nanoparticles have therapeutic potential against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. Novel therapeutics also include the implication of extracellular vesicles (EVs) to protect from SARS-CoV-2 viral infection.
View Article and Find Full Text PDFOncolytic virus purification with periodic counter-current chromatography.
Biotechnol Bioeng
September 2021
iBET, Instituto de Biologia Experimental e Tecnológica, Oeiras, Portugal.
Virus-based biologicals are one of the most promising biopharmaceuticals of the 21st century medicine and play a significant role in the development of innovative therapeutic, prophylactic, and clinical applications. Oncolytic virus manufacturing scale can range from 5 L in research and development up to 50 L for clinical studies and reach hundreds of liters for commercial scale. The inherent productivity and high integration potential of periodic counter-current chromatography (PCC) offer a transversal solution to decrease equipment footprint and the reduction of several non-value-added unit operations.
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