Adsorption of hemin and globin onto fibrous carboxymethylcellulose (CMC) that is commonly used in food industry was studied. The process of CMC saturation with hemin (and globin) was shown to depend on time and temperature. Constants for adsorption and the activation energy for the adsorption of globin were determined. A Langmuir-type hyperbolic adsorption was observed for globin, whereas the hemin adsorption on CMC was linear. Optimum conditions for globin isolation from hemoglobin solutions were found.
Download full-text PDF |
Source |
---|
Phys Chem Chem Phys
October 2024
Solid State and Structural Chemistry Unit, Indian Institute of Science, Bengaluru 560012, Karnataka, India.
spectroscopic investigations during molecular redox processes provide unique insights into complex molecular structures and their transformations. Herein, a combination of a potentiodynamic method with spectroscopy has been employed to holistically investigate the structural transformations during Fe-redox (Fe ↔ Fe) of hemin vis á vis heme-proteins, myoglobin (Mb), hemoglobin (Hb) and cytochrome- (Cyt-). The UV-vis findings reveal the formation of hemozoin (≈heme-dimer), which can be selectively prevented a high concentration of strongly interacting ligands, histidine (the fifth coordinating ligand in the heme-based protein).
View Article and Find Full Text PDFAnal Cell Pathol (Amst)
October 2024
Shantou University Medical College, Shantou, Guangdong Province, China.
PLoS One
August 2024
Department of Prenatal Diagnosis, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Background: Haemoglobin H (HbH) disease is caused by a disorder of α-globin synthesis, and it results in a wide range of clinical symptoms. M6A methylation modification may be one of the mechanisms of heterogeneity. Therefore, this article explored the role of methyltransferase like 16 (METTL16) in HbH disease.
View Article and Find Full Text PDFEcotoxicol Environ Saf
September 2024
Institute of Environment and Ecology, Tsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen 518055, China. Electronic address:
Previous studies reported that hemoprotein CYP450 catalyzed triclosan coupling is an "uncommon" metabolic pathway that may enhance toxicity, raising concerns about its environmental and health impacts. Hemoglobin, a notable hemoprotein, can catalyze endogenous phenolic amino acid tyrosine coupling reactions. Our study explored the feasibility of these coupling reactions for exogenous phenolic pollutants in plasma.
View Article and Find Full Text PDFToxicol In Vitro
August 2024
College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China. Electronic address:
Hemoglobin (Hb) is effective inducer for lipid oxidation and protein-polyphenol interaction is a well-known phenomenon. The effects of the interaction of (-)-epigallocatechin gallate (EGCG) with Hb on lipid oxidation were rarely elucidated. The detailed interaction between bovine Hb and EGCG was systematically explored by experimental and theoretical approaches, to illustrate the molecular mechanisms by which EGCG influenced the redox states and stability of Hb.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!