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Production of Organic Precursors via Meteoritic Impacts and Its Implications for Prebiotic Inventory of Early Planetary Surfaces.
Astrobiology
January 2025
NASA Goddard Space Flight Center, Greenbelt, Maryland, USA.
Meteoritic impacts on planetary surfaces deliver a significant amount of energy that can produce prebiotic organic compounds such as cyanides, which may be a key step to the formation of biomolecules. To study the chemical processes of impact-induced organic synthesis, we simulated the physicochemical processes of hypervelocity impacts (HVI) in experiments with both high-speed C projectiles and laser ablation. In the first approach, a C beam was accelerated to collide with ammonium nitrate (NHNO) to reproduce the shock process and plume generation of meteoritic impacts on nitrogen-rich planetary surfaces.
View Article and Find Full Text PDFPhoto-induced chirality in a nonchiral crystal.
Science
January 2025
Max Planck Institute for the Structure and Dynamics of Matter, Hamburg, Germany.
Chirality, a pervasive form of symmetry, is intimately connected to the physical properties of solids, as well as the chemical and biological activity of molecular systems. However, inducing chirality in a nonchiral material is challenging because this requires that all mirrors and all roto-inversions be simultaneously broken. Here, we show that chirality of either handedness can be induced in the nonchiral piezoelectric material boron phosphate (BPO) by irradiation with terahertz pulses.
View Article and Find Full Text PDFArterial stiffness mediates insulin resistance-related risk of atherosclerotic cardiovascular disease: a real-life, prospective cohort study.
Eur J Prev Cardiol
January 2025
Department of Cardiology, Kailuan General Hospital, Tangshan 063001, Hebei, CN.
Background: The precise pathways connecting insulin resistance (IR) to atherosclerotic cardiovascular disease (ASCVD) remain undefined. The present study aimed to examine the mediating role of arterial stiffness in the association between IR and ASCVD, providing epidemiology insights into the potential mechanisms driving IR to incident ASCVD.
Methods: A total of 59,777 participants from the Kailuan Study Arterial Stiffness Subcohort who were free of ASCVD at baseline were enrolled in the present study.
The impact of virtual reality on maternal anxiety, satisfaction, and fetal outcomes among pregnant women undergoing non-stress tests: A systematic review and meta-analysis of randomized controlled trials.
Health Care Women Int
January 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
We aimed to investigate the impact of virtual reality (VR) on maternal anxiety, satisfaction, and fetal physiological parameters during non-stress test (NST) in pregnant women. We conducted an extensive search across numerous databases to identify eligible studies from inception to April 2024. Researchers included randomized trials that compared VR intervention during NSTs in the third trimester with control groups.
View Article and Find Full Text PDFChronotropic effects of milrinone in a guinea pig ex vivo model: a pilot study to screen for new mechanisms of action.
J Cardiovasc Pharmacol
January 2025
Division of Clinical Physiology, Department of Cardiology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Positive inotropic responses upon administration of milrinone, an inhibitor of the phosphodiesterase enzyme (PDE), involve a well-pronounced positive chronotropic effect. Here we tested whether milrinone evokes this chronotropic response solely by PDE inhibition or by a concerted action that involve additional pharmacological targets. Milrinone stimulated increases in heart rate were studied in right atrial preparations of guinea pig in the presence or absence of inhibitors of putative ancillary molecular pathways or ion channels: i.
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