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The establishment of PD-1 inhibitor treatment prognosis model based on dynamic changes of peripheral blood indexes in patients with advanced lung squamous cell carcinoma.
Front Oncol
December 2024
Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Article Synopsis
- Patients with lung squamous cell carcinoma (LUSC) show limited benefits from targeted therapies, but immunotherapy, particularly PD-1 inhibitors, has emerged as a potential treatment option, although responses vary among individuals.
- A study analyzed data from 212 LUSC patients undergoing PD-1 combination therapy, focusing on making sense of various hematological indices at different treatment stages to find predictors for treatment outcomes and survival analysis.
- Findings revealed specific hematological markers (like SCC and NSE levels) significantly correlate with progression-free survival (PFS) and overall survival (OS), suggesting their potential as independent indicators for predicting patient prognosis in LUSC.
Elevated neurofilament light chain associated with cobalt/chromium metal neurotoxicity in a patient with a failed hip implant.
Clin Chim Acta
December 2024
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address:
Background: It is known that the heavy metals cobalt and chromium are associated with neurotoxicity. Chromium (Cr) and Cobalt (Co) are both components of metal-on-metal (MoM) implants which can be degraded/fragmented and released into the bloodstream. Neurofilament Light Chain (NfL) is a neuron-specific protein that increases in serum following axonal damage.
View Article and Find Full Text PDFMultimodal Deep Learning Fusing Clinical and Radiomics Scores for Prediction of Early-Stage Lung Adenocarcinoma Lymph Node Metastasis.
Acad Radiol
December 2024
School of Public Health, Jiangxi Medical College, Nanchang University, Nanchang 330006, China (C.X., L.D., W.C., M.H.); Jiangxi Provincial Key Laboratory of Disease Prevention and Public Health, Nanchang University, Nanchang 330006, China (C.X., L.D., W.C., M.H.). Electronic address:
Rationale And Objectives: To develop and validate a multimodal deep learning (DL) model based on computed tomography (CT) images and clinical knowledge to predict lymph node metastasis (LNM) in early lung adenocarcinoma.
Materials And Methods: A total of 724 pathologically confirmed early invasive lung adenocarcinoma patients were retrospectively included from two centers. Clinical and CT semantic features of the patients were collected, and 3D radiomics features were extracted from nonenhanced CT images.
Impedimetric Biosensors for the Quantification of Serum Biomarkers for Early Detection of Lung Cancer.
Biosensors (Basel)
December 2024
Faculty of Engineering and Applied Sciences, Cranfield University, Cranfield, Bedfordshire MK43 0AL, UK.
Lung cancer is the most common type of cancer diagnosed worldwide and is also among the most fatal. Early detection, before symptoms become evident, is fundamental for patients' survival. Therefore, several lung cancer biomarkers have been proposed to enable a prompt diagnosis, including neuron-specific enolase (NSE) and carcinoembryonic antigen (CEA).
View Article and Find Full Text PDFDrive Pressure-Guided Individualized Positive End-Expiratory Pressure in Traumatic Brain Injury Surgery: A Randomized Controlled Trial.
Ann Ital Chir
December 2024
Department of Anesthesiology, Institute of Anesthesia, Emergency and Critical Care, Northern Jiangsu People's Hospital Affiliated to Yangzhou University, 225002 Yangzhou, Jiangsu, China.
Aim: Intraoperative lung-protective ventilation strategies (LPVS) have been shown to improve lung oxygenation and prevent postoperative pulmonary problems in surgical patients. However, the application of positive end-expiratory pressure (PEEP)-based LPVS in emergency traumatic brain injury (TBI) has not been thoroughly explored. The purpose of this study is to evaluate the effects of drive pressure-guided individualized PEEP on perioperative pulmonary oxygenation, postoperative pulmonary complications, and recovery from neurological injury in patients with TBI.
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