1. PDGF is a highly hydrophilic cationic glycoprotein (M(r) 28-35kDa) produced by platelets, monocyte/macrophages, endothelial cells and vascular smooth muscle cells under some conditions. 2. Since its original description, PDGF has attracted much attention and it is currently believed to play a role in atherosclerosis and other vascular pathologies. 3. This review describes the vascular biology of PDGF. It particularly focuses on recent findings regarding the intracellular signals activated by PDGF in the context of vascular smooth muscle cell proliferation, migration and, contraction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/s0306-3623(96)00060-2 | DOI Listing |
Publication Analysis
Top Keywords
vascular smooth
12
smooth muscle
12
pdgf
5
vascular
5
platelet-derived growth
4
growth factor
4
factor pdgf
4
pdgf actions
4
actions mechanisms
4
mechanisms vascular
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!