Background: A 42-year-old white female complaining of decreased vision was examined and small golden particles were found in the macular regions of both eyes. It was ascertained that the patient had been using an oral bronzing agent, canthaxanthine (Orobronze), for the previous 10 years.
Methods: The method of deposition of these crystalline particles and their possible sequela are presented. The differential diagnosis of this condition is also described.
Results: In this case a crystalline retinopathy was induced by the oral ingestion of a bronzing agent.
Conclusions: Although the gold-like particles have no visual consequences, it is important for the clinician and the patient to be aware of their etiology.
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Asia Pac J Ophthalmol (Phila)
March 2023
University of Illinois at Chicago, Chicago, IL.
This study will provide a thorough review of systemic (and select intravitreal) medications, along with illicit drugs that are capable of causing various patterns of retinal toxicity. The diagnosis is established by taking a thorough medication and drug history, and then by pattern recognition of the clinical retinal changes and multimodal imaging features. Examples of all of these types of toxicity will be thoroughly reviewed, including agents that cause retinal pigment epithelial disruption (hydroxychloroquine, thioridazine, pentosan polysulfate sodium, dideoxyinosine), retinal vascular occlusion (quinine, oral contraceptives), cystoid macular edema/retinal edema (nicotinic acid, sulfa-containing medications, taxels, glitazones), crystalline deposition (tamoxifen, canthaxanthin, methoxyflurane), uveitis, miscellaneous, and subjective visual symptoms (digoxin, sildenafil).
View Article and Find Full Text PDFOphthalmic Surg Lasers Imaging Retina
December 2020
Limited information is known about the extent of canthaxanthin crystalline retinopathy on the retinal layers. The authors describe a 51-year-old woman who was taking canthaxanthin for tanning purposes for 7 years. Three years after cessation of this agent, she presented with asymmetric crystalline retinopathy affecting both eyes.
View Article and Find Full Text PDFArch Soc Esp Oftalmol (Engl Ed)
August 2018
Departamento de Oftalmología, Hospital Italiano de Buenos Aires, , Buenos Aires, Argentina.
Introduction: Canthaxanthin is a chemical product used to tan the skin. Its most frequent adverse effect is canthaxanthin retinopathy.
Purpose/ Methods: Report, case series.
Retina
December 2017
Department of Ophthalmology and Visual Sciences, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.
Purpose: To analyze macular pigment (MP) amount and distribution in patients with macular telangiectasia Type 2 receiving oral zeaxanthin supplementation in a randomized, open-label, interventional trial.
Methods: Eight macular telangiectasia Type 2 patients were randomized to 10 mg or 20 mg of zeaxanthin per day. At each visit, best-corrected visual acuity, contrast sensitivity, fundus biomicroscopy, color fundus photography, autofluorescence imaging, optical coherence tomography, and serum carotenoid levels were tested.
Ophthalmic Res
February 2017
Department of Ophthalmology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Multifocal electroretinography (mfERG) is an objective, noninvasive examination for the assessment of visual function. It enables the stimulation of multiple retinal areas simultaneously and recording of each response independently, providing a topographic measure of retinal electrophysiological activity in the central 40-50° of the retina. A clinical application of mfERG represents the assessment of retinal toxicity associated with systemic medications.
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