In order to study the recent rock-water interaction processes in the E1 Berrocal site, a sequential leaching method has been applied to granitic fracture fillings to obtain the U isotopic distribution in the mineral phases of these samples. Based on the mineralogical composition of these materials, six dissolution steps have been chosen to extract U as exchangeable cation, from carbonates, amorphous Fe-oxyhydroxides, labile resistates and highly insoluble resistates. In this way, the processes involved in the rock-water interaction phenomena, mainly dissolution, precipitation, coprecipitation and adsorption can be distinguished and even approximately dated.
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http://dx.doi.org/10.1016/s0969-8043(96)00089-9 | DOI Listing |
J Hazard Mater
January 2025
State Key Laboratory of Loess and Quaternary Geology, Xi'an AMS Center, Institute of Earth Environment, Chinese Academy of Sciences, Xi'an 710061, PR China; Shaanxi Key Laboratory of Accelerator Mass Spectrometry Technology and Application, Xi'an 710061, PR China. Electronic address:
Radiation risk through seafood consumption is a big public concern under the discharge of nuclear contaminated water. Plutonium is an important radionuclide in view of radiation risk due to its high radiological and chemical toxicity, as well as consistent presence in the environment. The distribution and level of plutonium isotopes (Pu, Pu) in marine biota collected along the coast of China in 2022-2023 were investigated.
View Article and Find Full Text PDFBackground: Intrathecally (IT) delivered antisense oligonucleotides (ASOs) are promising therapies that can reduce tau pathology in Alzheimer's Disease (AD). However, current plasma and CSF sampling methods to estimate brain tissue exposure of ASOs are inherently limited, hampering ASO clinical developmental plans. We developed the PET tracer [F]BIO-687, which binds ASO conjugates (ASO-Tz) in vivo, allowing us to image ASO distribution in a living brain using "pretargeted" imaging.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Huntington Medical Research Institutes, Pasadena, CA, USA.
Background: Dicarboxylic acids (DCAs) are critically important for intermediate metabolism. Since mitochondrial dysfunction and energy dysregulation are associated with AD pathology, we hypothesize that fluctuations in plasma DCAs would accompany AD pathology.
Method: In an ongoing brain-aging study, we recruited older adults (>65 years) classified as cognitively healthy (CH) after neuropsychological testing.
Alzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: Insulin resistance (IR) is associated with abnormal tau-phosphorylation and IR markers in AD brain co-localize with neurofibrillary tangles. One strategy to overcome brain IR is to increase brain insulin is via intranasal insulin (INI) administration using specialized intranasal devices that deliver insulin to the brain. Our recent INI vs.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Background: The G protein-coupled receptor GPR39 is heavily associated with the pathogenesis of neurologic disorders, including Alzheimer's disease (AD) and related dementia (ADRD). Its dysregulation of zinc 2+ (Zn) processes triggers metallic dyshomeostasis, oxidative stress, neuroinflammation, microtubule destabilization, synaptic dysfunction, and tau phosphorylation-all hallmarks of neurodegeneration. Hence, pharmacologic modulation of GPR39 could offer an effective treatment against AD and ADRD.
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