Several novel phosphatidic acid derivatives of 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine were synthesized, which contained dialkylphosphatidyl, dialkylthiophosphatidyl moieties, as well as diacylphosphatidyl moiety with either 14,14,14-trifluoro-12-oxatetradecanoyl or natural acyl residues inherent in egg yolk phosphatidylcholine. Diacylphosphatidyl derivatives of glycyrrhetinic acid were also prepared. All the synthesized compounds exhibited significant anti-HIV activity. The glycyrrhetinic acid derivatives are of special interest because of their low toxicity and a supposedly different mechanism of action.
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