The aim of the study was to examine the aggressive behavior of rats after lithium hydroxybutyrate injections (10 mg/kg once a day, at 9 a.m or 7 p.m., for a week). It was found that the drug did not affect the aggressive behavior of isolated rats towards mice placed to them. However, in the evening the drug inhibited aggressive manifestations (attacks, bites) in rats with raphe midbrain lesions. The 5-hydroxytryptophan (20 mg/kg, intraperitoneally, once) augmented the antiaggressive properties of lithium hydroxybutyrate in the evening but weakened them in the morning.
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