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Integrative clinico-biological, pharmacogenetic, neuroimagistic, neuroendocrinological and psychological correlations in depressive and anxiety disorders.
Rom J Morphol Embryol
August 2018
Discipline of Pedopsychiatry, Department of Neurosciences, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania; Department of Anatomy and Embryology, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania;
Article Synopsis
- - This study examines how modern treatment strategies for depression and anxiety in children and adolescents can be enhanced by using pharmacogenetic testing, neurobiological assessments, and psychological evaluations to tailor personal therapies.
- - Conducted between 2010 and 2016, the research involved 80 participants, split into two groups: one that received pharmacogenetic testing for therapy selection and one that did not.
- - Results indicated that the group with pharmacogenetic testing showed significantly better clinical outcomes, including improved depression scores, better overall functioning, and fewer side effects, suggesting the importance of personalized treatment approaches in managing these disorders.
[Neuroimaging of psychiatric and pedopsychiatric disorders].
Med Sci (Paris)
September 2011
Unité 1000 Inserm, CEA, université Paris Sud, université Paris Descartes; Maison de Solenn, Maison des adolescents, Hôpital Cochin, 97, boulevard de Port Royal, 75014 Paris, France.
Over the last two decades, imaging techniques have allowed to establish the cerebral neurophysiologic correlates of psychiatric disorders and have highlighted the impact of psychopathologic events, therapeutic drugs, addictions, on the growth and plasticity of brain. In this review, we intend to illustrate how neuroimaging has improved our knowledge of such alterations in brain maturation (schizophrenia, autistic disorders), fronto-limbic (depressive syndromes) or fronto-striatal (compulsive disorders) regions in psychiatric illnesses, but also in psychopharmacology, or pedopsychiatry. Statistically significant alterations in the structure and/or function of brain are detected in all psychiatric disorders and these are often detectable already during childhood or teenage.
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