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Diagnostic Value of Combined Test of Anti-Cyclic Citrullinated Peptide Antibody, AKA Antibody, Carp Antibody, and Rheumatoid Factor for Rheumatoid Arthritis.
Int J Rheum Dis
January 2025
Department of Rheumatism, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, China.
Objective: To analyze the diagnostic value of a combined test of anti-cyclic citrullinated peptide antibody (CCP), anti-keratin antibody (AKA), anti-carbamylated protein antibody (Carp antibody), and rheumatoid factor (RF) in the early diagnosis of rheumatoid arthritis (RA).
Methods: Sixty cases of RA admitted to our hospital from 2021 to 2022 (observation group) were selected, along with 50 cases of healthy physical examiners (control group). The results of CCP antibody, AKA antibody, Carp antibody, and rheumatoid factor in both groups were analyzed: the concentration of CCP antibody, AKA antibody, Carp antibody, and rheumatoid factor in each group at different levels; the comparison of various testing methods with the "gold standard" test; and the ROC curve analysis of CCP antibody, AKA antibody, Carp antibody, and rheumatoid factor in each group.
Association of RIPK1 and RIPK2 Gene Polymorphisms with Rheumatoid Arthritis in a Chinese Han Population.
Appl Clin Genet
October 2024
Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Article Synopsis
- - The study investigates the role of specific genetic variations (SNPs) in the RIPK1 and RIPK2 genes in contributing to the development of rheumatoid arthritis (RA), a complex autoimmune disease.
- - Researchers analyzed data from 394 RA patients and 258 normal controls to assess the relationship between these genetic markers and various inflammatory and biochemical parameters associated with RA.
- - The results revealed a strong link between the RIPK1 rs17548629 genotype and RA, along with significant correlations with markers like anti-CCP and RF, indicating its potential importance in understanding and diagnosing the disease.
BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images.
Am J Physiol Gastrointest Liver Physiol
July 2024
Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Children's Healthcare of Atlanta and Emory University School of Medicine, Atlanta, Georgia, United States.
The progress of research focused on cholangiocytes and the biliary tree during development and following injury is hindered by limited available quantitative methodologies. Current techniques include two-dimensional standard histological cell-counting approaches, which are rapidly performed, error prone, and lack architectural context or three-dimensional analysis of the biliary tree in opacified livers, which introduce technical issues along with minimal quantitation. The present study aims to fill these quantitative gaps with a supervised machine-learning model (BiliQML) able to quantify biliary forms in the liver of anti-keratin 19 antibody-stained whole slide images.
View Article and Find Full Text PDFA study of the roles of some immunological biomarkers in the diagnosis of rheumatoid arthritis.
J Med Life
August 2023
Al-Nasiriyah Technical Institute, Southern Technical University, Ministry of Higher Education and Scientific Research, Thi-Qar, Iraq.
Autoimmune rheumatoid arthritis (RA) is a systemic condition closely correlated with a variety of autoantibodies (Abs) that could be considered diagnostic and prognostic markers. The current research was designed to detect the diagnostic values for a number (n) of these auto-Abs in RA detection and to evaluate the accuracy of a combined diagnostic scheme. This prospective study was conducted between September 2021 and August 2022 and included 110 subjects with RA, 70 individuals with other autoimmune disorders as positive controls (PC), and 50 unrelated, apparently healthy individuals as healthy controls (HC).
View Article and Find Full Text PDF[Significance of IgA isotype of anti-v-raf murine sarcoma viral oncogene homologue B1 antibody in rheumatoid arthritis].
Beijing Da Xue Xue Bao Yi Xue Ban
August 2023
Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China.
Objective: To detect serum IgA isotype of anti-v-raf murine sarcoma viral oncogene homologue B1 (BRAF) antibody levels in the rheumatoid arthritis (RA) patients in order to investigate their clinical significance in RA.
Methods: Serum samples were obtained from 61 RA patients, 21 osteoarthritis (OA) patients, 16 systemic lupus erythematosus (SLE) patients, 16 gout patients, 16 Sjögren's syndrome (SS) patients and 22 healthy controls. IgA isotype of anti-BRAF antibody levels in the sera were examined by enzyme-linked immunosorbent assay (ELISA).
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