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Background: Three blood-based biomarkers of neurological injury-glial fibrillary acidic protein (GFAP), neurofilament light (Nf-L), and Tau-have emerged as promising biomarkers of neurological disorders and injuries such as hypoxic-ischemic encephalopathy (HIE), traumatic brain injury, and Alzheimer's disease (AD). The low levels of GFAP, Nf-L, and Tau in serum and plasma require highly sensitive assays to detect them. Here, we report the analytical validation of an ultrasensitive, electrochemiluminescence-based, multiplexed immunoassay for neurological biomarker assessment.
View Article and Find Full Text PDFNew Ionic Liquid Forms of Antituberculosis Drug Combinations for Optimized Stability and Dissolution.
AAPS PharmSciTech
January 2025
Department of Pharmaceutics, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Isoniazid (INH) and rifampicin (RIF) are the two main drugs used for the management of tuberculosis. They are often used as a fixed drug combination, but their delivery is challenged by suboptimal solubility and physical instability. This study explores the potential of active pharmaceutical ingredient-ionic liquids (API-ILs) to improve the physicochemical and pharmaceutical properties of INH and RIF.
View Article and Find Full Text PDFDual-mode ratiometric optical sensor for rapid visual detection of Hg with poly(adenine)-assisted silver nanoclusters anchoring on tetrahedral DNA framework.
Mikrochim Acta
January 2025
College of Chemistry and Environmental Engineering, Sichuan University of Science and Engineering, Zigong, 643000, P.R. China.
Cytosine-rich and poly(adenine)-tailed tetrahedral DNA framework (TDF) is designed as template (A-TDF) for anchoring silver nanoclusters (AgNCs) and igniting the dual-color fluorescence of AgNCs. The resultant DNA-AgNCs simultaneously emits red and green fluorescence, and the quantum yield of red fluorescence is as high as 44.8%.
View Article and Find Full Text PDFExploring the intricate studies on low-density polyethylene (LDPE) biodegradation by Bacillus cereus AP-01, isolated from the gut of Styrofoam-fed Tenebrio molitor larvae.
Biodegradation
January 2025
Centre of Advanced Study in Marine Biology, Faculty of Marine Sciences, Annamalai University, Parangipettai, Tamilnadu, 608502, India.
Article Synopsis
- The study investigates how well a gut bacteria strain, Bacillus cereus AP-01, can break down low-density polyethylene (LDPE), using experiments over 28 days to measure its effectiveness.
- The researchers employed various methods like FTIR and SEM to analyze changes in LDPE structure and confirmed the bacterial strain through molecular characterization.
- Results showed that the bacteria significantly degraded LDPE, with a 30.3% weight loss and changes in mechanical properties, highlighting its potential as a solution for plastic pollution.
In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics.
Invest Ophthalmol Vis Sci
January 2025
Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States.
Purpose: Aqueous humor inflow rate, a key parameter influencing aqueous humor dynamics, is typically measured by fluorophotometry. Analyzing fluorophotometric data depends, inter alia, on the volume of aqueous humor in the anterior chamber but not the posterior chamber. Previous fluorophotometric studies of the aqueous inflow rate in mice have assumed the ratio of anterior:posterior volumes in mice to be similar to those in humans.
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