The author offers an original method of the study of the midbrain structures and liquor circulation system (the third ventricle, brain water-pipe, the fourth ventricle) in the small cavity in the course of autopsy. The position of the middle structures is characterized by means of the angle measuring of their borders against bone structures of the base and vault of the skull. The method allows to assess morphometrically the degree of dislocation of the middle structures in pathological conditions accompanied by brain edema.
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Environ Sci Pollut Res Int
January 2025
Earth Sciences, Engineering Faculty, Autonomous University of San Luis Potosi, Av. Manuel Nava 8, San Luis Potosí, SLP, Mexico.
Ecosystems such as wetlands have karst groundwater as their primary source of preserving their services and functions. Karst systems are complex hydrogeological systems that are difficult to study because of their complicated functioning mechanism, which requires an interdisciplinary effort based on hydrodynamic assessment and characterization of the hydrogeology of the system. The study area is the Ramsar wetland Ciénaga de Tamasopo (Mexico), which is dependent on the discharge of karst groundwater that is affected by water extraction of extensive sugarcane agriculture and is also the main water source for the rural towns.
View Article and Find Full Text PDFImmunol Invest
January 2025
Department of Oncology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Lung Cancer Institute, Jinan, China.
Tissue-resident memory T (TRM) cells possess unique abilities to migrate, establish themselves in tissues, and monitor peripheral tissues without circulating. They are crucial in providing long-lasting and local immune protection against surface infections. TRMs demonstrate distinct phenotypic and functional characteristics compared to central memory T (Tcm) cells and effector memory T (Tem) cells.
View Article and Find Full Text PDFAdv Healthc Mater
January 2025
Nitte (Deemed to be University), Department of Bio & Nano Technology, Nitte University Centre for Science Education and Research, Mangalore, Karnataka, 575018, India.
Therapeutic strategy for efficiently targeting cancer cells needs an in-depth understanding of the cellular and molecular interplay in the tumor microenvironment (TME). TME comprises heterogeneous cells clustered together to translate tumor initiation, migration, and proliferation. The TME mainly comprises proliferating tumor cells, stromal cells, blood vessels, lymphatic vessels, cancer-associated fibroblasts (CAFs), extracellular matrix (ECM), and cancer stem cells (CSC).
View Article and Find Full Text PDFEur Heart J Case Rep
January 2025
Cardiology Department, Loyola University Medical Center, 2160 S 1st Ave, Maywood, IL 60153-3328, USA.
Background: Immune checkpoint inhibitors (ICIs) are effective antineoplastic agents but can cause adverse effects in many organ systems. Cardiovascular toxicities include arrhythmias, myocarditis, heart failure, takotsubo syndrome, pericarditis, coronary artery disease, and vasculitis.
Case Summary: A 66-year-old woman with Stage 3C2 endometrial carcinoma presented for her second cycle of pembrolizumab, carboplatin, and paclitaxel.
J Inflamm Res
January 2025
Department of Biomedical Science, Charles E. Schmidt College of Medicine, Florida Atlantic University, Jupiter, FL, USA.
Major Depressive Disorder (MDD) is a common and severe neuropsychiatric condition resulting in irregular alterations in affect, mood, and cognition. Besides the well-studied neurotransmission-related etiologies of MDD, several biological systems and phenomena, such as the hypothalamic-pituitary-adrenal (HPA) axis, reactive oxygen species (ROS) production, and cytokine signaling, have been implicated as being altered and contributing to depressive symptoms. However, the manner in which these factors interact with each other to induce their effects on MDD development has been less clear, but is beginning to be understood.
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