A close relationship between the ADN pool and one of the routes of free radical generation mediated by the xanthine oxidase system has been revealed during studies of changes in adenyl nucleotide metabolism in 140 patients with acute myocardial infarction. The metabolic disorders and changes in the activities of free-radical processes associated with them were found to correlate in patients with different forms of acute myocardial infarction during the acute stage of the disease. The authors consider that this correlation gives grounds for including antioxidative agents in the treatment protocols.
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