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Decellularized cartilage tissue bioink formulation for osteochondral graft development.
Biomed Mater
January 2025
Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, United States of America.
Articular cartilage and osteochondral defect repair and regeneration presents significant challenges to the field of tissue engineering (TE). TE and regenerative medicine strategies utilizing natural and synthetic-based engineered scaffolds have shown potential for repair, however, they face limitations in replicating the intricate native microenvironment and structure to achieve optimal regenerative capacity and functional recovery. Herein, we report the development of a cartilage extracellular matrix (ECM) as a printable biomaterial for tissue regeneration.
View Article and Find Full Text PDFExtracellular vesicles support increased expansion of mesenchymal stromal cells on fetal membrane-derived decellularized extracellular matrix.
Cell Tissue Res
December 2024
Department of Obstetrics, Gynaecology and Newborn Health, University of Melbourne, Royal Women's Hospital Campus, Parkville, VIC, Australia.
Article Synopsis
- DMSC-derived extracellular vesicles (DMSC_EV) were shown to enhance DMSC proliferation and mobility on specific growth surfaces, particularly s-dAM.
- DMSC attachment varied based on the substrate, with increased attachment observed on decellularized surfaces and Matrigel when EVs were included.
- The study highlights that combining in vitro EVs and extracellular matrix (ECM) components can optimize the expansion and therapeutic potential of mesenchymal stem cells (MSCs) for various applications.
Characterization of a decellularized pericardium extracellular matrix hydrogel for regenerative medicine: insights on animal-to-animal variability.
Front Bioeng Biotechnol
August 2024
Department of Health Sciences, University of Piemonte Orientale "A. Avogadro", Novara, Italy.
In the past years, the use of hydrogels derived from decellularized extracellular matrix (dECM) for regenerative medicine purposes has significantly increased. The intrinsic bioactive and immunomodulatory properties indicate these materials as promising candidates for therapeutical applications. However, to date, limitations such as animal-to-animal variability still hinder the clinical translation.
View Article and Find Full Text PDFAn integrative alginate-based 3D in vitro model to explore epithelial-stromal cell dynamics in the breast tumor microenvironment.
Carbohydr Polym
October 2024
i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 5 Porto, Portugal; INEB - Instituto de Engenharia Biomédica, Universidade do Porto, Porto, Portugal; ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal. Electronic address:
The tumor microenvironment (TME) orchestrates cellular and extracellular matrix (ECM) interactions, playing a key role in tumorigenesis, tumor growth, and metastization. Investigating the interplay between stromal-epithelial cells within the TME is paramount for understanding cancer mechanisms but demands reliable biological models. 3D-models have emerged as powerful in vitro tools, but many fall short in replicating cell-cell/cell-matrix interactions.
View Article and Find Full Text PDFEffect of accelerated aging on shelf-stability, product loss, sensory and biochemical characteristics in 2 lower quality beef cuts.
Meat Sci
July 2024
Kansas State University, Department of Animal Sciences and Industry, Manhattan, KS 66506, USA. Electronic address:
The aim of this study was to determine the impact of accelerated aging (AA) on shelf stability, product loss, sensory and biochemical characteristics of 2 lower quality beef cuts. Triceps brachii (TB) and semimembranosus (SM) were collected and fabricated from 10 USDA Choice beef carcasses and assigned to 1 of 6 treatments: 3 d cooler aged (control), 21 d cooler aged, AA 49 °C for 2 h, AA 49 °C for 3 h, AA 54 °C for 2 h, and AA 54 °C for 3 h. The results showed that AA can decrease APC counts on steak surface and in purge and redness, but increase lightness and product loss of the steaks (P < 0.
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