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Effect of Bioplastic Material on Adhesion, Growth, and Proliferative Activity of Human Fibroblasts When Incubated in Solutions Mimic the Acidity of Wound an Acute and Chronic Inflammation.
Dokl Biochem Biophys
October 2024
National Medical Research Centre for Rehabilitation and Balneology' of the Ministry of Health of Russia, Moscow, Russia.
Unlabelled: One of the key stages of wound healing is the phase of inflammation, which is a transitional process between hemostasis and wound healing. Each stage of the inflammatory-reparative process is characterized by its own value of the acidity of the wound bed. For example, in the acute stage of inflammation, the acidity of the medium in the wound bed decreases to pH 5.
View Article and Find Full Text PDFSynergistic effects of rivaroxaban and hypothermia or acidosis on coagulation initiation measured with ROTEM: a prospective observational study.
Thromb J
October 2024
The Medical Faculty, Lund University Sweden Sölveg, Lund, 223 62, Sweden.
Background: Hypothermia and acidosis individually inhibit haemostasis. We designed this study with the aim to investigate whether rivaroxaban combined with hypothermia or acidosis exhibit synergistic inhibitory effects on haemostasis using ROTEM.
Methods: Patients with a clinical indication to start rivaroxaban treatment were prospectively included.
The effects of acidemia and acidemia reversal on coagulation in dogs.
Front Vet Sci
September 2024
College of Veterinary Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Background: The effect of acidemia on blood coagulation remains inadequately understood in veterinary medicine. Therefore, we assessed the effect of acidification of canine whole blood on coagulation and investigated whether acidemia-induced coagulopathy could be reversed by reversing acidemia.
Methods: Citrated whole blood samples were taken from six healthy Beagle dogs and categorized, based on pH adjustment, into neutral, weak acidemia (WA), strong acidemia (SA), and reversal from SA.
[Damage Control Resuscitation and Damage Control Surgery].
Anasthesiol Intensivmed Notfallmed Schmerzther
June 2024
Trauma triggers complex physiological responses with primary and secondary effects vital to understanding and managing trauma impact. "Damage Control" (DC), a concept adapted from naval practices, refers to abbreviated initial surgical care focused on controlling bleeding and contamination, critical for the survival of severely compromised patients. This impacts anaesthesia procedures and intensive care.
View Article and Find Full Text PDFPathophysiology of Trauma-Induced Coagulopathy.
Hamostaseologie
February 2024
Department of Trauma and Orthopaedic Surgery, Cologne-Merheim Medical Center, University of Witten/Herdecke, Cologne-Merheim Campus, Cologne, Germany.
Trauma-induced coagulopathy (TIC) is a complex hemostatic disturbance that can develop early after a major injury. There is no universally accepted definition of TIC. However, TIC primarily refers to the inability to achieve sufficient hemostasis in severely injured trauma patients, resulting in diffuse microvascular and life-threatening bleeding.
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