The majority of recombination events detected within the mouse major histocompatibility complex (MHC) fall into regions of limited physical distance known as hot spots of meiotic recombination. The hot spot associated with the Ea gene appears to be active only in the presence of the p allele carried by the intra-MHC recombinant strain BIO.F(13R). To study the frequency, regulation, and haplotype specificity of recombination at the Ea hot spot, progeny from three different backcrosses involving BIO.F(13R) were screened for recombination events across the MHC using DNA microsatellite markers. Screening of a total of 750 backcross progeny permitted the identification of seven recombinants within the Ea gene. Using restriction site polymorphisms, and sequence-based nucleotide polymorphisms, the recombination breakpoints in all seven Ea recombinants were mapped to two adjacent segments of 71 bp and 346 bp in intron 4 of the Ea gene.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1101/gr.6.3.195 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ferroptosis in kidney disease: a bibliometric analysis from 2012 to 2024.
Front Pharmacol
January 2025
Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
Background And Aims: Ferroptosis, a novel concept of programmed cell death proposed in 2012, in kidney disease, has garnered significant attention based on evidence of abnormal iron deposition and lipid peroxidation damage in the kidney. Our study aim to examine the trends and future research directions in the field of ferroptosis in kidney disease, so as to further explore the target or treatment strategy for clinical treatment of kidney disease.
Material And Methods: A thorough survey using the Web of Science Core Collection, focusing on literature published between 2012 and 2024 examining the interaction between kidney disease and ferroptosis was conducted.
Unveiling significant regrowth and potential risk of nontuberculous mycobacteria in hospital water supply system.
Water Res
January 2025
Department of Urban Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo 113-8656, Japan; Research Center for Advanced Science and Technology, The University of Tokyo, 4-6-1, Komaba, Meguro, Tokyo 153-8904, Japan. Electronic address:
The health burden of waterborne nontuberculous mycobacteria (NTM) is a rising concern. While the water supply systems can serve as a potential reservoir for NTM, their abundance, diversity, and transmission pathways remain unknown. This study aimed to characterize the prevalence and regrowth of NTM in building water supply system in a hospital where many M.
View Article and Find Full Text PDFA local shrinkage approach for creating dynamic hot-spots on thermoresponsive nanocellulose-based SERS substrate.
J Colloid Interface Sci
January 2025
College of Light Industry and Food Engineering, Nanjing Forestry University, Jiangsu Co-Innovation Center for Efficient Processing and Utilization of Forest Resources, Nanjing 210037 China. Electronic address:
Surface-enhanced Raman scattering (SERS) is a highly sensitive technology to detect target analytes. The construction of dynamic "hot-spots" represents a significant approach to enhancing detection sensitivity. Herein, a hybrid plasma platform with dynamic "hot-spots" was developed for SERS recognition based on the assembly of gold nanospheres (AuNSs) on temperature-sensitive bacterial cellulose (BC) film grafted with poly(N-isopropylacrylamide) (PNIPAM).
View Article and Find Full Text PDFDesign and Fabrication of MoCuO Bimetallic Oxide Electrodes for High-Performance Micro-Supercapacitor by Electro-Spark Machining.
Micromachines (Basel)
December 2024
Department of Mechatronic Engineering, Guangdong Polytechnic Normal University, Guangzhou 510665, China.
Transition metal oxides, distinguished by their high theoretical specific capacitance values, inexpensive cost, and low toxicity, have been extensively utilized as electrode materials for high-performance supercapacitors. Nevertheless, their conductivity is generally insufficient to facilitate rapid electron transport at high rates. Therefore, research on bimetallic oxide electrode materials has become a hot spot, especially in the field of micro-supercapacitors (MSC).
View Article and Find Full Text PDFRacial and Geographic Disparities in Colorectal Cancer Incidence and Associated County-Level Risk Factors in Mississippi, 2003-2020: An Ecological Study.
Cancers (Basel)
January 2025
Program in Public Health, Stony Brook Medicine, Stony Brook, NY 11794, USA.
Introduction: Colorectal cancer (CRC) is the third most commonly diagnosed cancer in the United States (U.S.).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!