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The Major Role of T Regulatory Cells in the Efficiency of Vaccination in General and Immunocompromised Populations: A Review.
Vaccines (Basel)
August 2024
Department of Urology, The University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA.
Article Synopsis
- Vaccines have played a crucial role in controlling pandemics since the smallpox vaccine, including the recent COVID-19 outbreak, by activating various immune cells like CD4 and CD8 T cells and B cells.
- Research shows that specific T regulatory cells, like Treg and Tr1, influence how effective vaccines are, especially for immunocompromised individuals.
- Strategies to enhance vaccine efficacy include adjusting dosages, changing administration routes, giving booster shots, and using monoclonal antibodies to minimize Treg activity and stimulate stronger immune responses.
Contribution of Tregs to the promotion of constructive remodeling after decellularized extracellular matrix material implantation.
Mater Today Bio
August 2024
School of Medicine, South China University of Technology, 510006, Guangzhou, Guangdong, China.
Host remodeling of decellularized extracellular matrix (dECM) material through the appropriate involvement of immune cells is essential for achieving functional organ/tissue regeneration. As many studies have focused on the role of macrophages, only few have evaluated the role of regulatory T cells (Tregs) in dECM remodeling. In this study, we used a mouse model of traumatic muscle injury to determine the role of Tregs in the constructive remodeling of vascular-derived dECM.
View Article and Find Full Text PDFInterleukin-2/anti-interleukin-2 complex attenuates inflammation in a mouse COPD model by expanding CD4 CD25 Foxp3 regulatory T cells.
Int Immunopharmacol
April 2024
Department of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Beijing, China; National Center for Respiratory Medicine, Beijing, China; State Key Laboratory of Respiratory Health and Multimorbidity, China. Electronic address:
Background And Purpose: Chronic, nonspecific inflammation of the alveoli and airways is an important pathological feature of chronic obstructive pulmonary disease (COPD), while sustained inflammatory reactions can cause alveolar damage. Regulatory T cells (Tregs) inhibit inflammation, whereas the interleukin-2/anti-interleukin-2 complex (IL-2C) increases the number of Tregs; however, whether the IL-2C has a therapeutic role in COPD remains unknown. Therefore, this study investigated whether IL-2C alleviates lung inflammation in COPD by increasing the number of Tregs.
View Article and Find Full Text PDF2,3,5,4'- tetrahydroxystilbene-2-O-β-D- glucopyranoside (TSG)-Driven immune response in the hepatotoxicity of Polygonum multiflorum.
J Ethnopharmacol
May 2024
Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan Province, 410008, China; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha, Hunan Province, 410078, China; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, Changsha, Hunan Province, 410078, China. Electronic address:
Ethnopharmacological Relevance: 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside (TSG) as the primary constituent of Polygonum multiflorum Thumb. (PM) possesses anti-oxidative, antihypercholesterolemic, anti-tumor and many more biological activities. The root of PM has been used as a tonic medicine for thousands of years.
View Article and Find Full Text PDFEstablishing a novel and sensitive assay for bioactivity determination of anti-CD25 antibodies.
Heliyon
June 2023
Key Laboratory of the Ministry of Health for Research on Quality and Standardization of Biotech, Division of Monoclonal Antibody Products, National Institutes for Food and Drug Control, Beijing 102629, China.
Anti-CD25 antibodies have been approved for renal transplantation and has been used prior to and during transplantation by the Food and Drug Administration (FDA). However, no reported bioassays have been reflected the mechanism of action (MOA) of anti-CD25 antibodies. Here, we describe the development and validation of a reporter gene assay (RGA) based on the engineered C8166-STAT5RE-Luc cells expressing endogenous IL-2 receptors and a STAT5-inducible element-driven firefly luciferase in C8166 cell lines.
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