AI Article Synopsis
- Cefuroxime concentrations in rat blood were measured at 30 and 60 minutes after administering different particle sizes of its amorphous form and a crystal form of its ester.
- The HPLC method was used to estimate cefuroxime levels, showing a close correlation between the particle size of the amorphous form and bioavailability, with smaller particles yielding higher concentrations.
- In contrast, the crystal form of cefuroxime ester was poorly absorbed, resulting in similar blood concentrations to larger particles of the amorphous form in both in vivo and in vitro settings.
Article Abstract
Concentrations of cefuroxime [II] in blood of rats were measured 30 and 60 min. after administration of amorphous form possessing various particles size (ranging from 0.09 to 0.4 nm) and crystal form of 1-acethoxyethyl ester of cefuroxime [I]. In vitro the concentrations of [II] were measured 15 and 45 min. after application of [I]. HPLC method was used for cefuroxime estimation. Close correlation between the particles size of the amorphous [I] and the concentrations of [II] in vivo as well as in vitro was found, the particles with lover size possessed higher bioavailability. The cefuroxime front the crystal form of ester is poorly absorbed and the concentrations of [II] after its application were similar to those observed after of the bigest particles of amorphous form both in vivo and in vitro.
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