[Study of plasma and hepatic hydrolysis of nitroxinil derivatives].

Ann Pharm Fr

Laboratoire de Chimie Pharmaceutique, Faculté de Pharmacie, Toulouse.

Published: January 1997

Seven esters derivatives of Nitroxinil were prepared and their structures were assigned by IR and 1H-NMR spectroscopy. The rate of plasma and hepatic hydrolysis were evaluated in vitro in sheep and rabbit. In view of this profile of activity, pivaloyl derivative merits evaluation, in vivo.

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