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Article Synopsis
  • - A 61-year-old man experienced urinary and defecation issues for 4 months, leading to an abdominal contrast-enhanced CT that showed large rectal masses suspected to be cancerous and affecting nearby organs.
  • - An 18 F-FDG PET/CT scan was conducted for staging, revealing intense activity in masses involving the rectum, bladder, prostate, left ureter, and abdominal wall in the pelvic area.
  • - Further histopathological analysis identified the masses as malakoplakia, characterized by specific cells (von Hansemann cells) and unique structures known as Michaelis-Gutmann bodies.
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Prostatic malakoplakia: clinicopathological assessment of a multi-institutional series of 49 patients.

Histopathology

October 2022

Department of Pathology and Laboratory Medicine of The Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, USA.

Prostatic malakoplakia (MP) is rare, with only case reports and small series (< five patients) available in the literature. In this study we analysed an international multi-institutional series of 49 patients with prostatic MP to more clearly define its clinicopathological features. The median age was 67 years and the median serum prostate-specific antigen (PSA) was 7.

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Background: Malakoplakia is a chronic inflammatory disease characterized by tissue infiltrates of large granular macrophages containing distinctive intracytoplasmic inclusions termed Michaelis-Gutmann (MG) bodies. The genitourinary system is the most commonly involved site, followed by the gastrointestinal tract. Malakoplakia may occur as a complication of primary or secondary immunosuppression and, therefore, renal transplant recipients are at risk.

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